Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at ge[...]

Throwing arm injuries are common because of the demand on the shoulder. Shoulder exams and pitching mechanics are regularly monitored by team physicians. Excessive instab[...]

Gene prediction, a fundamental task in genomics, plays a pivotal role in decipheringthe functional elements of genomes. However, accurate gene prediction remains a challe[...]

Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the[...]

Computational modeling of protein–DNA complex structures has important implications in biomedical applications such as structure-based, computer aided drug design. A key [...]

Single-stranded DNA (ssDNA) binding proteins are crucial for biological processes including replication, transcription, and genomic integrity. We can better comprehend th[...]

Gene regulation networks (GRNs) are the bases for virtually all biological processes. To gain a global understanding of GRNs encoded in a genome, we first need to identif[...]

Mutations are a primary source of genetic variation and a major driving force in evolution by influencing survivability (fitness), genetic disease, and the development of[...]

How to deal with the long-range electrostatic interactions theoretically and computationally has been well studied due to their importance in biological processes and tim[...]

Sporadic Amyotrophic lateral sclerosis (sALS) is a complex, invariably fatal, disease with a poorly understood cause, despite many studies. Diagnostic biomarkers that pre[...]