DNA-binding proteins are involved in essential biological processes including gene expression, DNA packaging and DNA repair. They bind to DNA target sequences with differ[...]

Hydrogen bonds play a vital role in protein-DNA interactions. In particular, side chain-base hydrogen bonds are crucial to the binding specificity between protein and DNA[...]

Hydrogen bond donors (HBDs) have been explored as potential catalysts for the 1,4-conjugate addition and Diels-Alder reactions. HBD catalysis, which relies on Brønsted a[...]