Perceived work ability (PWA) represents an employee’s perceptions of their ability to continue working in their current job given their personal resources and the characteristics of their job, and relates to many positive organizational outcomes (e.g., increased well-being, decreased absenteeism). Using the model of selection, optimization and compensation (SOC) as a theoretical framework, the current study investigated two potential moderators of the relationship between SOC strategy use and perceived work ability—general health status (personal resource) and perceived job control (contextual resource). Two interactions were hypothesized: a) a two-way interaction where the SOCPWA relationship would be strongest for those with lower perceptions of health, regardless of age, and b) a three-way interaction where the SOC-PWA relationship would be strongest for those with lower perceptions of health and higher perceptions of job control, regardless of age. It was hypothesized that SOC strategy use, general health status, and perceived job control would predict PWA directly as well. A two-wave MTurk sample (N = 466) was used to test this model. Both general health status and perceived job control predicted PWA, while SOC strategy use did not. Both hypothesized interactions were not significant, though age was a significant predictor of PWA in the final regression model. Supplemental analyses were conducted to further investigate results including the inclusion of overall job demands as an additional control variable. Limitations such as sampling and measurement issues are discussed as well as what future studies should consider when studying the SOC-PWA relationship.