As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaire[...]

Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis ar[...]

Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative [...]

Over 80% of all malaria deaths occur in children under 5 years of age. Malaria controlstrategies have been progressively shifted to specific populations and/or areas to m[...]

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till da[...]

The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key p[...]

Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by[...]

Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) pathways, it remains unknown how the APE2 gene is altered in the human [...]

The current gold standard for gamete preservation is cryogenic storage. Dry preservation is an attractive alternative, eliminating the need for refrigeration, reducing s[...]

Recent advancements in single-cell RNA sequencing have revolutionized our understanding of gene expression regulation under various biological contexts, providing higher [...]