This study utilized a grounded theory approach to examine the degree to which oncology nurses report posttraumatic growth (PTG) and wisdom as a result of caring for patients. Open-ended interviews were conducted with 30 oncology nurses; interviews were designed to elicit information regarding how nurses had positively changed as a result of their work experience. Findings were grouped into four major themes that coincided with the primary aims of the study: Loss and Challenges to Nurses' Assumptive Worlds, Posttraumatic Growth, Wisdom, and the Relationship Between PTG and Wisdom. Overall, nurses unanimously cited examples of PTG and wisdom that resulted from their work. Subthemes of Posttraumatic Growth were largely consistent with the five domains of PTG and included Appreciation of Life, New Perspective, Relating to Others, Spiritual/Religious Growth, and Personal Strength. Subthemes of wisdom were more varied, reflecting the diversity of this construct in the context of oncology nursing. A number of other related themes emerged from the data, including Positive Consequences and Professional Knowledge/Expertise. Findings suggest that the relationship between PTG and wisdom was circuitous and constantly evolving, although there was some evidence for a positive association between these two constructs. The theme of Benevolence also appeared to be closely related to PTG and wisdom. Limitations and suggestions for future research are also presented.