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New perspectives on SNARE function in the yeast minimal endomembrane system
Title
New perspectives on SNARE function in the yeast minimal endomembrane system
Author
Chi, Richard J., Grissom, James H., Segarra, Veronica A.
Subjects--Topical
Endocytosis, Cells
Description
Saccharomyces cerevisiae is one of the best model organisms for the study of endocytic membrane trafficking. While studies in mammalian cells have characterized the temporal and morphological features of the endocytic pathway, studies in budding y...
Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle
Title
Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle
Author
Arthur, Susan, Howden, Reuben, Zwetsloot, Kevin, Shanely, Andrew
Subjects--Topical
Musculoskeletal system, Cells
Description
Abstract. – BACKGROUND: The declining myogenic potential of aged skeletal muscle is multifactorial. Insufficient satellite cell activity is one factor in this process. Notch andWnt signaling are involved in various biological processes including o...
GSI treatment preserves protein synthesis in C2C12 myotubes
Title
GSI treatment preserves protein synthesis in C2C12 myotubes
Author
Arthur, Susan, Huot, Joshua, Marino, Joseph S., Thompson, Brian, McMullen, Charlotte
Subjects--Topical
Muscle proteins, Cells
Description
It has been demonstrated that inhibiting Notch signaling through γ-secretase inhibitor (GSI) treatment increases myogenesis, AKT/mTOR signaling, and muscle protein synthesis (MPS) in C2C12 myotubes. The purpose of this study was to determine if GS...