Search results | J. Murrey Atkins Library

Title: Notch inhibition via GSI treatment elevates protein synthesis in C2C12 myotubes
Author: Arthur, Susan, Huot, Joshua, Marino, Joseph S., Turner, Michael
Subjects--Topical: Proteins--Synthesis, Muscle proteins
Description: The role of Notch signaling is widely studied in skeletal muscle regeneration but little is known about its influences on muscle protein synthesis (MPS). The purpose of this study was to investigate whether Notch signaling is involved in the regul...

Title: The association of COPD exacerbations with new onset type 2 diabetes among Medicare patients
Author: Marino, Joseph S., Ruban, Cynthiya, Saunders, Bill, Blanchette, Christopher M.
Subjects--Topical: Lungs--Diseases, Obstructive, Non-insulin-dependent diabetes
Description: Objective: Chronic obstructive pulmonary disease (COPD) is highly prevalent in the elderly population and typically reduces overall quality of life. Exacerbations of COPD are commonly treated with corticosteroids, a class of drug known to cause in...

Title: GSI treatment preserves protein synthesis in C2C12 myotubes
Author: Arthur, Susan, Huot, Joshua, Marino, Joseph S., Thompson, Brian, McMullen, Charlotte
Subjects--Topical: Muscle proteins, Cells
Description: It has been demonstrated that inhibiting Notch signaling through γ-secretase inhibitor (GSI) treatment increases myogenesis, AKT/mTOR signaling, and muscle protein synthesis (MPS) in C2C12 myotubes. The purpose of this study was to determine if GS...

Title: Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
Author: Marino, Joseph S., Dreau, Didier, Marriott, Ian, Bennett, Jeanette M.
Date Created: 2022
Subjects--Topical: Cancer cells, Lungs--Cancer
Description: Lung cancer maintains a relatively small survival rate (~19%) over a 5-year period and up to 80-85% of all lung cancer diagnoses are Non-Small Cell Lung Cancer (NSCLC). To determine whether metformin reduces non-small cell lung cancer (NSCLC) LL/2...