The majority of US women have used oral contraceptives at some point in their lives and approximately 5% have used hormone replacement therapy (HRT). Few studies have investigated the association between these hormonal regimens and periodontitis, and results have been conflicting. The objective of the current study was to determine if women who had ever used oral contraceptives or hormonal replacement therapy had increased odds of periodontitis. This study was a secondary data analysis of 2011-2012 National Health and Nutrition Examination Survey (NHANES) data. Multivariate logistic regression was used to calculate odds ratios and 95% confidence intervals. After adjusting for age, race/ethnicity, income, education, and alcohol use, women who had ever used oral contraceptives had decreased odds of periodontitis, however, the result was not statistically significant (OR=0.74, 95% CI: 0.36-1.50). After adjusting for race/ethnicity, income, education, last dental visit, smoking and marital status, women who had ever used hormonal replacement therapy had slightly increased odds of periodontitis (OR=1.17, 95% CI: 0.55-2.49). The evidence regarding the association between the use of oral contraceptives and periodontitis is conflicting and the evidence regarding the association between hormonal replacement therapy and periodontitis is sparse. Additional research is needed utilizing large, nationally representative samples to determine the true association between these hormone regimens and periodontitis. Understanding this association can assist dentists and other health care providers in taking better care of women who use these regimens.