This multi-site study assessed newly licensed, newly hired nurses to determine whether their professional experiences contribute to the development of posttraumatic growth (PTG) and well-being. Also, how world assumptions, coping, social support, and/or nursing specific stress contribute to outcomes of interest. Nurses (N = 49) completed questionnaires within three weeks of their first nursing position and again eight and sixteen weeks later. Findings indicated that nurses reported growth at relatively stable levels over the course of the study and at similar or higher levels to previous cross-sectional studies with similar helping professions. Repeated-measures mixed modeling indicated that greater stress associated with work-specific events (p = .006), challenges to one's core beliefs (p < .001), and less use of the coping style behavioral disengagement (p = .004) were all significantly associated with week sixteen PTG. However, social support (both professional and personal) did not significantly contribute to the model. Analyses also indicated that while challenges to one's core beliefs/world assumptions predicted PTG, the nature of the beliefs (more positive or negative) were not associated with PTG, affirming that it is the examination of one's core beliefs/world assumptions that contributes to growth and not necessarily the content. Directions for future research and potential implications concerning possible strengths-based trainings and interventions for nurses are discussed.