Neural engineering is the application of engineering processes and principles to the nervous system for treatment against diseases and disorders such as Neurodegeneration, Mental Health, Peripheral Neuropathy, Etc. Through the application of novel technologies such as additive manufacturing, microfluidics, and advanced imaging techniques, mechanistic insights of neuromodulation can be determined to help develop key therapeutics. Neuromodulation is an aspect of Neural Engineering which focuses on development of modulatory techniques to alter neuronal functions through stimulation methods such as, chemical, mechanical, electrical etc. Stimulation techniques such as Electrical Stimulation (ESTIM) and Magnetic Stimulation (MSTIM) focus on external electric field induction in pulsed patterns which mimic action potential firing rates. Through modification in frequency patterning, neurons can be excited or depressed, changing characteristics such as growth, energy production, synapse formation and plasticity. This study focuses on the development and application of Electrical Stimulation (ESTIM) and Magnetic Simulation (MSTIM) to enhance mitochondrial trafficking in Dorsal Root Ganglion neurons as a protective mechanism against Chemotherapy Induced Peripheral Neuropathy (CIPN). CIPN is a dose limiting side effect of chemotherapy treatment which causes discomfort and pain due to induced degeneration of axon fibers translated as a tingling sensation in the patients’ extremities such as fingertips and feet. Initially, this study focused on neuroprotective effects of FDA approved drug Fluocinolone Acetonide (FA) against CIPN, where FA was found to enhance axon length and mitochondrial trafficking after anticancer drug treatment. Enhanced mitochondrial trafficking by FA led us to believe mitochondrial play a key role in neuroprotection of axon fibers. Through development of neuromodulation techniques, we studied the effect of ESTIM and MSTIM against CIPN through frequency dependent control of mitochondrial trafficking.