Human-wildlife interactions and conflicts are becoming increasingly common over time, as humans and wildlife are sharing more space and resources than previously. These interactions and conflicts negatively affect humans in direct and indirect ways, but also have important consequences for wildlife populations, with conflict species being more prone to extinction. In this era of rapid global change, we should strive to coexist with wildlife populations, for our own benefit and theirs. Long-term human-wildlife coexistence requires (1) an understanding of species life history, threats, and interactions, (2) proper management of negative interactions and conflicts that is suitable for both human and wildlife populations, and (3) the use of conservation measures to protect species and the resources they need. The interaction of these three dimensions will allow us to evaluate human-wildlife interactions in more depth that highlights both the social and environmental contributing factors, and by ensuring that all three dimensions are incorporated into interactions, we can work towards promoting long-term coexistence between humans and wildlife. This dissertation includes four different research chapters, all working to promote long-term coexistence between human and raptor populations by building our knowledge of species spatial ecology, evaluating management actions for conflicts, and assessing potential conservation needs. In Chapter Two, I discuss plastic ingestion by black vulture (Coragyps atratus) and turkey vulture (Cathartes aura) populations, providing information on threats as well as opportunities for future conservation actions. In Chapter Three, I introduce RaPTR, an online GIS spatial decision support system that helps raptor rehabilitators select suitable release sites for raptors that maximize the chances of post-release survival while minimizing the chances of human-wildlife conflict and the time and effort required by rehabilitators. In Chapter Four, I present research on human-black vulture conflicts, providing a deeper understanding of the contributing factors to conflicts and the best long-term management strategies. Finally, in Chapter Five, I discuss the current black vulture range change and future projected expansions and contractions in the range across the United States, aiming to provide knowledge that can promote better conflict management and conservation actions as needed. Combined, these research chapters fill some knowledge gaps, expose others, and highlight opportunities for raptor conflict management and conservation that will promote long-term human-raptor coexistence going forward.