In contemporary society, individuals with substance abuse histories face a multitude of challenges that extend far beyond the physical and psychological effects of addiction. As they embark on the path of recovery and strive for reintegration into society, they are confronted with an additional formidable barrier: the pervasive stigma and discrimination that persistently accompany their past struggles. This dissertation seeks to illuminate the profound impact of stigma and discrimination on individuals with substance abuse histories, exploring the underlying factors that perpetuate these harmful attitudes, and proposing potential strategies to alleviate their burden. Comprised of three interconnected papers, this research analyzes trust dynamics, stigma, and social support towards this population, offering valuable insights for combating stigma and fostering a more inclusive and compassionate society. The first paper focuses on the power of counter stereotypical information to counteract negative stereotypes and enhance trust in everyday interactions involving individuals with substance abuse histories. By examining the ways in which positive information mitigate stigmatizing attitudes, this paper uncovers strategies to promote understanding and empathy in social encounters, paving the way for more meaningful connections and reduced discrimination. Moving forward, the second paper explores participants' perceptions of trust and trustworthiness when engaging with partners with varying substance abuse histories in a trust game. By investigating how participants' knowledge of their partners' backgrounds influences expectations of reciprocity and trustworthiness, this paper unravels the complex dynamics that shape trust evaluations in interpersonal relations. The findings highlight how challenging preconceptions can transform perceptions, dismantle biases, and foster a more inclusive and empathetic society. Lastly, the third paper investigates the psychological and relational factors that influence cooperation and support towards individuals with substance abuse histories within familial and friendship networks. By identifying the barriers that hinder cooperation and providing recommendations for creating supportive environments, this paper aims to strengthen social support networks and facilitate a more compassionate and inclusive community for individuals facing substance abuse challenges.Collectively, these three papers contribute to the broader goal of combating stigma, building trust, and fostering cooperation towards individuals with substance abuse histories. The findings underscore the pivotal role of counter stereotypical information, perceptions of warmth and trustworthiness, and the significance of individual attitudes and social support networks in reducing stigma and cultivating an environment that promotes recovery. By revealing the complexities of stigma and discrimination, this dissertation aspires to inform policies and interventions that empower individuals with substance abuse histories to thrive and reintegrate into society with dignity and respect.