Despite being more likely to encounter, endure, and report higher levels of distress, African Americans are less likely to seek and persist with mental health services. Similarly, African Americans are more likely to report negative attitudes toward help-seeking. Of the numerous barriers influencing negative attitudes, mental health stigma is identified as the most significant barrier. The purpose of this study was to examine factors that may influence attitudes towards seeking psychological help in African American adults. More specifically, the study investigated if, and to what extent, a relationship existed between help-seeking attitudes and three subtypes of stigma (public, social, and self). In addition to this, the study also explored the moderating effect of generation, gender and race centrality. A total sample of 190 African American participants were recruited from across the United States and completed an online survey involving self-report questions. An OLS multiple linear regression analysis was utilized. The results indicated that two of the three types of stigma significantly predicted help-seeking attitudes. The relationship between stigma and mental health seeking attitudes was also found to be moderated by gender on two of the three stigma scales. Implications of this study includes broaching conversations about mental health stigma, designing psychoeducational and outreach programs focusing on the destigmatizing of mental health treatment and the increase of mental health literacy as a means of promoting positive help seeking attitudes, and remedying the current practice of offering a single course in multicultural counseling. These results offer an empirical base for further exploration.