The impact of stress and other psychological variables on Inflammatory Bowel Disease (IBD) prognosis, treatment response, and functional level is well established. However, typical IBD treatment focuses on the physiological pathology of the disease and neglects complementary stress-reducing interventions. Recent pilot studies report the benefits of mindfulness-based interventions in people living with IBD; however, these studies have small sample sizes. Recruitment challenges may be in part due to the difficulty IBD patients often have adhering to set schedules as a result of IBD symptoms such as pain, fatigue, and incontinence. The current study aimed to address this barrier by offering participants access to mindfulness training online, allowing individuals to engage with intervention materials in a comfortable environment with scheduling flexibility. Online mindfulness programs have gained popularity in recent years, as they increase access and flexibility and decrease cost to the user; however, the dropout rate tends to be high. The current study compared the rate of adherence and efficacy of mindfulness training as a function of level of support: self –guided versus supported. Analysis revealed no significant difference in the benefits received between participants in the two groups; however group assignment significantly impacted the rate of intervention completion. Common challenges to meditation were measured, but did not significantly predict adherence to the intervention. Implications of the current research, future directions for the use of mindfulness-based intervention for IBD patients and a discussion of methodological considerations are provided.