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ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
Title
ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
Author
Singer, Christopher
Date Created
2019
Subjects--Topical
Bioinformatics, Biophysics, Physics
Description
Protein thermodynamics has been shown to be insightful and illuminating to the functional mechanisms behind biological function. By characterizing proteins and protein families according to their enthalpy and entropy we can make inferences to the ...
Elucidating Dynamic Mechanisms for Extended Spectrum Antibiotic Resistance in Class A Beta-Lactamase through Machine Learning on Molecular Dynamics Simulations
Title
Elucidating Dynamic Mechanisms for Extended Spectrum Antibiotic Resistance in Class A Beta-Lactamase through Machine Learning on Molecular Dynamics Simulations
Author
Avery, Christopher
Date Created
2019
Subjects--Topical
Biophysics, Physics
Description
Beta-lactamase is a protein which is produced in bacteria and is a primary cause of antibiotic resistance to Beta Lactam antibiotics. Beta Lactams are among the most common types of antibiotics (including penicillin) and thus understanding the res...
PREPARATION AND VISUALIZATION OF INDIVIDUAL ACTIN FILAMENTS USING ATOMIC FORCE MICROSCOPY FOR THE STUDY OF ACTIN/DNA HYDROGEL COMPLEXES
Title
PREPARATION AND VISUALIZATION OF INDIVIDUAL ACTIN FILAMENTS USING ATOMIC FORCE MICROSCOPY FOR THE STUDY OF ACTIN/DNA HYDROGEL COMPLEXES
Author
Kennedy, Joshua
Date Created
2019
Subjects--Topical
Physics, Biophysics, Biomedical engineering
Description
A protocol of sample preparation for the visualization of single actin filaments at the nanoscale using atomic force microscopy for use in studies of engineered actin/DNA conjugated hydrogel complexes was developed. Hydrogels are cross-linked netw...