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Cytosolic DNA sensors and glial responses to endogenous DNA
Title
Cytosolic DNA sensors and glial responses to endogenous DNA
Author
Marriott, Ian, Suptela, Alexander J.
Date Created
2023
Subjects--Topical
Genomics, DNA
Description
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Title
Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Author
Marriott, Ian, Jeffries, Austin M., Suptela, Alexander J.
Date Created
2022
Subjects--Topical
Herpes simplex virus, DNA
Description
The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition receptors that include intracellular RNA an...