Search results
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Title
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Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
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Author
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Grdzelishvili, Valery, Goad, Dakota, Bressy, Christian, Holbrook, Molly
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Subjects--Topical
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Vesicular stomatitis, Cancer, Viruses
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Description
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Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against different malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies have demonstrated that VSV-based OVs are effective against the majority of...
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Title
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Biomotors, viral assembly, and RNA nanobiotechnology : current achievements and future directions
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Author
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Robland, Lewis, Beasock, Damian, Afonin, Kirill A., Schlick, Tamar
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Date Created
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2022
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Subjects--Topical
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Viruses, Nanotechnology
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Description
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The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent adv...
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Title
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Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
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Author
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Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
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Subjects--Topical
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Cancer, Viruses
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Description
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Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...
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Title
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FLAVi : an enhanced annotator for viral genomes of Flaviviridae
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Author
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Machado, Denis Jacob, Schneider, Adriano, Guirales, Sayal, Janies, Daniel
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Subjects--Topical
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Viruses, Phylogeny
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Description
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Responding to the ongoing and severe public health threat of viruses of the family Flaviviridae, including dengue, hepatitis C, West Nile, yellow fever, and Zika, demands a greater understanding of how these viruses emerge and spread. Updated phyl...
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Title
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Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
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Author
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Grdzelishvili, Valery, Hastie, Eric Lawrence, Cataldi, Marcela, Moerdyk-Schauwecker, Megan J., Felt, Sebastien A., Steuerwald, Nury
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Subjects--Topical
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Cancer, Viruses
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Description
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Vesicular stomatitis virus (VSV) based recombinant viruses (such as VSV-ΔM51) are effective oncolytic viruses (OVs) against a majority of pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to VSV...