Search results | J. Murrey Atkins Library

Title: Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
Author: Afonin, Kirill A., Truong, Nguyen, Halman, Justin
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Infusion reactions (IRs) create a translational hurdle for many novel therapeutics, including those utilizing nanotechnology. Nucleic acid nanoparticles (NANPs) are a novel class of therapeutics prepared by rational design of relatively short olig...

Title: Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author: Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry
Description: The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...

Title: The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Author: Afonin, Kirill A., Bila, Dominika, Panigaj, Martin
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach...

Title: The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author: Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical: Immunology, Nucleic acids, Nanoparticles
Description: Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...

Title: The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...

Title: Structure and composition define immunorecognition of nucleic acid nanoparticles
Author: Afonin, Kirill A.
Date Created: 2022, 2022, 2022
Subjects--Topical: Immune system, Interferon, Nucleic acids

Title: Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
Author: Afonin, Kirill A., Dobrovolskaia, Marina
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry

Title: Smart-responsive nucleic acid nanoparticles (NANPs) with the potential to modulate immune behavior
Author: Afonin, Kirill A., Chandler, Morgan
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acids are programmable and biocompatible polymers that have beneficial uses in nanotechnology with broad applications in biosensing and therapeutics. In some cases, however, the development of the latter has been impeded by the unknown imm...

Title: Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author: Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...

Title: Prevalence of alternative splicing choices in Arabidopsis thaliana
Author: Loraine, Ann, English, Adam C., Patel, Ketan S.
Date Created: 2010
Subjects--Topical: Gene expression, Nucleic acids
Description: Background: Around 14% of protein-coding genes of Arabidopsis thaliana genes from the TAIR9 genome release are annotated as producing multiple transcript variants through alternative splicing. However, for most alternatively spliced genes in Arabi...

Title: Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
Author: Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...

Title: Functionally-interdependent shape-switching nanoparticles with controllable properties
Author: Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
Subjects--Topical: Nucleic acids, Nanotechnology
Description: We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...

Title: Functionally-interdependent shape-switching nanoparticles with controllable properties
Author: Afonin, Kirill A., Halman, Justin, Chandler, Morgan
Date Created: 2017
Subjects--Topical: Nucleic acids, Chemistry
Description: We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...

Title: First step towards larger DNA-based assemblies of fluorescent silver nanoclusters: template design and detailed characterization of optical properties
Author: Afonin, Kirill A., Shevchenko, Oleg
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Besides being a passive carrier of genetic information, DNA can also serve as an architecture template for the synthesis of novel fluorescent nanomaterials that are arranged in a highly organized network of functional entities such as fluorescent ...

Title: Expanding structural space for immunomodulatory nucleic acid nanoparticles (NANPs) via spatial arrangement of their therapeutic moieties
Author: Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created: 2022
Subjects--Topical: Nucleic acids, Chemistry
Description: Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self-assemble into nucleic acid nanoparticles (NANPs). With this approach, therapeutic cocktails with preci...

Title: Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
Author: Afonin, Kirill A., Ke, Weina
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...

Title: Editorial for the special issue on nucleic acid architectures for therapeutics, diagnostics, devices and materials
Author: Afonin, Kirill A., Halman, Justin
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry

Title: DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
Author: Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...

Title: Consistency analysis of redundant probe sets on Affymetrix three-prime expression arrays and applications to differential mRNA processing
Author: Loraine, Ann, Cui, Xiangqin
Date Created: 2009
Subjects--Topical: Gene expression, Nucleic acids
Description: Affymetrix three-prime expression microarrays contain thousands of redundant probe sets that interrogate different regions of the same gene. Differential expression analysis methods rarely consider probe redundancy, which can lead to inaccurate in...

Title: ComparePD : improving protein–DNA complex model comparison with hydrogen bond energy-based metrics
Author: Guo, Jun-tao, Malik, Fareeha Kanwal
Date Created: 2023
Subjects--Topical: DNA, Nucleic acids
Description: Computational modeling of protein–DNA complex structures has important implications in biomedical applications such as structure-based, computer aided drug design. A key step in developing methods for accurate modeling of protein–DNA complexes is ...