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Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Title
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical
Immunology, Nucleic acids, Nanoparticles
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author
Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
Title
Toll-like receptor-mediated recognition of nucleic acid nanoparticles (NANPs) in human primary blood cells
Author
Afonin, Kirill A., Truong, Nguyen, Halman, Justin
Date Created
2019
Subjects--Topical
Nucleic acids, Chemistry
Description
Infusion reactions (IRs) create a translational hurdle for many novel therapeutics, including those utilizing nanotechnology. Nucleic acid nanoparticles (NANPs) are a novel class of therapeutics prepared by rational design of relatively short olig...