Search results
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Title
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Analysis of pollen-specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR
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Author
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Loraine, Ann, Estrada, April, Freese, Nowlan H., Blakley, Ivory
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Date Created
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2015
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Subjects--Topical
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Bioinformatics, Pollen, Nucleic acids
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Description
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Alternative splicing enables a single gene to produce multiple mRNA isoforms by varying splice site selection. In animals, alternative splicing of mRNA isoforms between cell types is widespread and supports cellular differentiation. In plants, at ...
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Title
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Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
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Author
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Afonin, Kirill A., Chandler, Morgan, Halman, Justin
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Date Created
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2022
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
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Title
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Characterization of cationic bolaamphiphile vesicles for sirna delivery into tumors and brain
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Author
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Afonin, Kirill A., Kim, Taejin, Gupta, Kshitij
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Date Created
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2020
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). Howeve...
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Title
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Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
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Author
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Afonin, Kirill A., Ke, Weina
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Date Created
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2020
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...
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Title
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Functionally-interdependent shape-switching nanoparticles with controllable properties
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Author
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Afonin, Kirill A., Halman, Justin, Chandler, Morgan
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Date Created
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2017
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
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Title
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Prevalence of alternative splicing choices in Arabidopsis thaliana
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Author
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Loraine, Ann, English, Adam C., Patel, Ketan S.
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Date Created
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2010
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Subjects--Topical
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Gene expression, Nucleic acids
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Description
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Background: Around 14% of protein-coding genes of Arabidopsis thaliana genes from the TAIR9 genome release are annotated as producing multiple transcript variants through alternative splicing. However, for most alternatively spliced genes in Arabi...