Search results | J. Murrey Atkins Library

Title: Analysis of pollen-specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR
Author: Loraine, Ann, Estrada, April, Freese, Nowlan H., Blakley, Ivory
Date Created: 2015
Subjects--Topical: Bioinformatics, Pollen, Nucleic acids
Description: Alternative splicing enables a single gene to produce multiple mRNA isoforms by varying splice site selection. In animals, alternative splicing of mRNA isoforms between cell types is widespread and supports cellular differentiation. In plants, at ...

Title: Biomotors, viral assembly, and rna nanobiotechnology: current achievements and future directions
Author: Afonin, Kirill A., Rolband, Lewis
Date Created: 2022
Subjects--Topical: Nucleic acids, Chemistry
Description: The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent adv...

Title: Change in lipofectamine carrier as a tool to fine-tune immunostimulation of nucleic acid nanoparticles
Author: Afonin, Kirill A., Newton, Hannah S., Xu, Jie
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimul...

Title: Characterization of cationic bolaamphiphile vesicles for sirna delivery into tumors and brain
Author: Afonin, Kirill A., Kim, Taejin, Gupta, Kshitij
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). Howeve...

Title: ComparePD : improving protein–DNA complex model comparison with hydrogen bond energy-based metrics
Author: Guo, Jun-tao, Malik, Fareeha Kanwal
Date Created: 2023
Subjects--Topical: DNA, Nucleic acids
Description: Computational modeling of protein–DNA complex structures has important implications in biomedical applications such as structure-based, computer aided drug design. A key step in developing methods for accurate modeling of protein–DNA complexes is ...

Title: Consistency analysis of redundant probe sets on Affymetrix three-prime expression arrays and applications to differential mRNA processing
Author: Loraine, Ann, Cui, Xiangqin
Date Created: 2009
Subjects--Topical: Gene expression, Nucleic acids
Description: Affymetrix three-prime expression microarrays contain thousands of redundant probe sets that interrogate different regions of the same gene. Differential expression analysis methods rarely consider probe redundancy, which can lead to inaccurate in...

Title: DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
Author: Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...

Title: Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
Author: Afonin, Kirill A., Ke, Weina
Date Created: 2020
Subjects--Topical: Nucleic acids, Chemistry
Description: RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...

Title: Expanding structural space for immunomodulatory nucleic acid nanoparticles (NANPs) via spatial arrangement of their therapeutic moieties
Author: Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
Date Created: 2022
Subjects--Topical: Nucleic acids, Chemistry
Description: Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self-assemble into nucleic acid nanoparticles (NANPs). With this approach, therapeutic cocktails with preci...

Title: First step towards larger DNA-based assemblies of fluorescent silver nanoclusters: template design and detailed characterization of optical properties
Author: Afonin, Kirill A., Shevchenko, Oleg
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Besides being a passive carrier of genetic information, DNA can also serve as an architecture template for the synthesis of novel fluorescent nanomaterials that are arranged in a highly organized network of functional entities such as fluorescent ...

Title: Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
Author: Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...

Title: Prevalence of alternative splicing choices in Arabidopsis thaliana
Author: Loraine, Ann, English, Adam C., Patel, Ketan S.
Date Created: 2010
Subjects--Topical: Gene expression, Nucleic acids
Description: Background: Around 14% of protein-coding genes of Arabidopsis thaliana genes from the TAIR9 genome release are annotated as producing multiple transcript variants through alternative splicing. However, for most alternatively spliced genes in Arabi...

Title: Smart-responsive nucleic acid nanoparticles (NANPs) with the potential to modulate immune behavior
Author: Afonin, Kirill A., Chandler, Morgan
Date Created: 2019
Subjects--Topical: Nucleic acids, Chemistry
Description: Nucleic acids are programmable and biocompatible polymers that have beneficial uses in nanotechnology with broad applications in biosensing and therapeutics. In some cases, however, the development of the latter has been impeded by the unknown imm...

Title: Special issue nanotechnology to overcome the world's most critical health issues: liposomes and beyond-a themed issue dedicated to Professor Yechezkel Barenholz
Author: Afonin, Kirill A., Dobrovolskaia, Marina
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry

Title: Structure and composition define immunorecognition of nucleic acid nanoparticles
Author: Afonin, Kirill A.
Date Created: 2022, 2022, 2022
Subjects--Topical: Immune system, Interferon, Nucleic acids

Title: The recognition of and reactions to nucleic acid nanoparticles by human immune cells
Author: Afonin, Kirill A., Bila, Dominika, Panigaj, Martin
Date Created: 2021
Subjects--Topical: Nucleic acids, Chemistry
Description: The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach...

Title: Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author: Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created: 2023
Subjects--Topical: Nucleic acids, Chemistry
Description: The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...