Search results
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Title
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Analysis of pollen-specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR
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Author
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Loraine, Ann, Estrada, April, Freese, Nowlan H., Blakley, Ivory
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Date Created
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2015
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Subjects--Topical
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Bioinformatics, Pollen, Nucleic acids
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Description
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Alternative splicing enables a single gene to produce multiple mRNA isoforms by varying splice site selection. In animals, alternative splicing of mRNA isoforms between cell types is widespread and supports cellular differentiation. In plants, at ...
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Title
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Functionally-interdependent shape-switching nanoparticles with controllable properties
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Author
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Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
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Subjects--Topical
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Nucleic acids, Nanotechnology
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Description
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We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
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Title
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Prevalence of alternative splicing choices in Arabidopsis thaliana
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Author
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Loraine, Ann, English, Adam C., Patel, Ketan S.
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Date Created
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2010
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Subjects--Topical
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Gene expression, Nucleic acids
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Description
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Background: Around 14% of protein-coding genes of Arabidopsis thaliana genes from the TAIR9 genome release are annotated as producing multiple transcript variants through alternative splicing. However, for most alternatively spliced genes in Arabi...
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Title
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Structure and composition define immunorecognition of nucleic acid nanoparticles
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Author
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Afonin, Kirill A.
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Date Created
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2022
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Subjects--Topical
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Immune system, Interferon, Nucleic acids
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Description
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Nucleic acid nanoparticles (NANPs) have evolved as a new class of therapeutics with the potential to detect and treat diseases. Despite tremendous advancements in NANP development, their immunotoxicity, one of the major impediments in clinical tra...
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Title
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The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
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Author
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Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
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Subjects--Topical
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Immunology, Nucleic acids, Nanoparticles
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Description
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Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...