Search results
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Title
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VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
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Author
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goyal, Shreya
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Date Created
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2021
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Subjects--Topical
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Biochemistry, Cytology, Molecular biology
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Description
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ABSTRACTCareful control of intracellular signaling pathways plays an important role in a cell’s ability to maintain stable internal conditions in the face of an ever-changing extracellular environment. This is particularly true as it relates to th...
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Title
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Understanding Chaperone interactions in disease
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Author
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Nitika
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Date Created
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2021
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Subjects--Topical
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Molecular biology, Biochemistry, Cytology
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Description
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The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...
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Title
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The role of the dopaminergic system in the regulation of physical activity in mice
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Author
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Knab, Amy
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Date Created
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2009
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Subjects--Topical
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Molecular biology, Genetics, Physiology
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Description
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Physical activity (PA) is important to human health, and the genetic and biological regulating factors of physical activity are only beginning to be understood. The dopamine (DA) system has been shown to regulate motivation, and locomotor behavior...
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Title
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THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
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Author
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Cupello, Steven
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Date Created
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2019
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Subjects--Topical
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Molecular biology, Biology, Cytology
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Description
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Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...
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Title
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THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
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Author
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McLeod, Melissa
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Date Created
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2016
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Subjects--Topical
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Molecular biology, Biology, Cytology
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Description
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Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...
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Title
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Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
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Author
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Suptela, Alexander
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Date Created
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2023
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Subjects--Topical
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Immunology, Molecular biology, Neurosciences
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Description
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Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...
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Title
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Role of Nonmuscle Myosin II in Hepatic Stellate Cell Activation
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Author
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Moore, Cathy
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Date Created
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2009
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Subjects--Topical
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Molecular biology
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Description
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The hepatic stellate cell (HSC) plays a pivotal role in the development of hepatic fibrosis. Regulation of liver microcirculation is a complex system where blood flow is under systemic and sinusoidal control. Upon a fibrogenic stimulus, quiescent ...
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Title
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Regulation of Myc and its Localization to Histone Locus Body in Drosophila
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Author
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Khan, Abid
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Date Created
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2012
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Subjects--Topical
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Molecular biology, Biology, Developmental biology
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Description
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Myc is a transcriptional factor required for normal growth and development in vertebrates and invertebrates alike. Loss of function mutations in Myc can cause embryonic lethality in mammals and larval death in flies whereas an increase in its acti...
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Title
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ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
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Author
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Mattocks, Matthew
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Date Created
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2010
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Subjects--Topical
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Molecular biology, Cytology, Oncology
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Description
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Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...
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Title
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REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
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Author
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Ha, Anh
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Date Created
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2020
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Subjects--Topical
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Molecular biology, Cytology
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Description
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Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...
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Title
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RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
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Author
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Daneshvar, Kaveh
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Date Created
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2012
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Subjects--Topical
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Molecular biology, Biology, Genetics
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Description
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Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...