Search results | J. Murrey Atkins Library

Title: Topoisomerase II Inhibitors Induce an Illegitimate Genome Rearrangement Common in Infant Leukemia
Author: Bariar, Bhawana
Date Created: 2013
Subjects--Topical: Molecular biology
Description: Infant acute leukemias account for ~30% of all malignancy seen in childhood across the Western world. They are aggressive and characterized by rapid onset shortly after birth. The majority of these have rearrangements involving the MLL (mixed line...

Title: Characterizing a New Regulator of the ATR Signaling Pathway
Author: Biller, Megan
Date Created: 2022
Subjects--Topical: Molecular biology, Biology
Description: Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...

Title: The Role of Metformin on Non-Small Cell Lung Cancer Progression and Skeletal Muscle Health.
Author: Bond, Nicole
Date Created: 2021
Subjects--Topical: Molecular biology, Kinesiology
Description: Lung cancer is the second most common cancer and maintains a relatively small survival rate (~20%). Non-Small Cell Lung Cancer (NSCLC) makes up 80-85% of all lung cancer diagnoses. Lung cancer patients routinely undergo surgical procedures, chemot...

Title: Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author: Bose, Mukulika
Date Created: 2022
Subjects--Topical: Molecular biology, Biochemistry, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...

Title: THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
Author: Cupello, Steven
Date Created: 2019
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...

Title: RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
Author: Daneshvar, Kaveh
Date Created: 2012
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...

Title: MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
Author: Felt, Sebastien
Date Created: 2017
Subjects--Topical: Molecular biology, Virology, Cytology
Description: Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...

Title: The Potential for Genistein, a Topoisomerase II Inhibitor, to Induce Inter-Chromosomal Homologous Recombination.
Author: French, Caroline
Date Created: 2023
Subjects--Topical: Molecular biology
Description: Maintenance of genome integrity is important for preventing mutagenic events and preserving overall cell functionality. DNA damaging agents induce DNA double strand breaks (DSBs) that are repaired through repair pathways non-homologous end-joining...

Title: Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Author: Gargey, Akhil
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Biophysics
Description: Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...

Title: APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author: HOSSAIN, MD AKRAM
Date Created: 2021
Subjects--Topical: Molecular biology, Biology, Cytology
Description: The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...

Title: REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
Author: Ha, Anh
Date Created: 2020
Subjects--Topical: Molecular biology, Cytology
Description: Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...

Title: Notch Serves as a Molecular Brake on Myogenesis, Protein Synthesis, and Growth in Skeletal Muscle
Author: Huot, Joshua
Date Created: 2018
Subjects--Topical: Molecular biology, Kinesiology
Description: Aging can be accompanied by aggressive loss of muscle mass (sarcopenia) and is a primary prognosticator for the reduced capacity of the elderly to accomplish basic activities of daily living. Several mechanisms within skeletal muscle lead to devel...

Title: Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Author: Kepple, Daniel
Date Created: 2022
Subjects--Topical: Biology, Molecular biology, Cytology
Description: Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. P. vivax was previously thought to be rare or absent in Africa because people of African descent often lack the ...

Title: Regulation of Myc and its Localization to Histone Locus Body in Drosophila
Author: Khan, Abid
Date Created: 2012
Subjects--Topical: Molecular biology, Biology, Developmental biology
Description: Myc is a transcriptional factor required for normal growth and development in vertebrates and invertebrates alike. Loss of function mutations in Myc can cause embryonic lethality in mammals and larval death in flies whereas an increase in its acti...

Title: The role of the dopaminergic system in the regulation of physical activity in mice
Author: Knab, Amy
Date Created: 2009
Subjects--Topical: Molecular biology, Genetics, Physiology
Description: Physical activity (PA) is important to human health, and the genetic and biological regulating factors of physical activity are only beginning to be understood. The dopamine (DA) system has been shown to regulate motivation, and locomotor behavior...

Title: Hepatic Stellate Cell Transdifferentiation: Pro-fibrogenic Effectors
Author: Lakner, Ashley
Date Created: 2011
Subjects--Topical: Molecular biology, Biology
Description: Hepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by excessive deposition of extracellular matrix components, predominantly type I collagen. Chronic injury stimula...

Title: Cell Type-Specific Double Strand Break Repair: An Inter-Chromosomal Homologous Recombination Study Using the Rainbow Mouse Model
Author: Lalwani, Kiran
Date Created: 2023
Subjects--Topical: Molecular biology, Cytology, Developmental biology
Description: Faithful repair of DNA lesions is central to maintaining genomic integrity. Illegitimate repair of chromosomal DNA damage, especially double-strand breaks (DSBs), can lead to mutations and genome rearrangements. Homologous recombination (HR) is a ...

Title: Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
Author: Lambirth, Kevin
Date Created: 2015
Subjects--Topical: Molecular biology, Biology, Bioinformatics
Description: The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...

Title: Circadian behavior and gene expression in an estuarine cnidarian, Nematostella vectensis
Author: Leach, Whitney
Date Created: 2019
Subjects--Topical: Molecular biology, Ecology
Description: Animals respond to diurnal shifts in their environment with a combination of behavioral, physiological, and molecular changes to synchronize with regularly-timed external cues. The light:dark cycle is regarded as the most important entrainment cue...

Title: ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
Author: Mattocks, Matthew
Date Created: 2010
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...