Search results

  • CSV Spreadsheet
  • RSS Feed
(1 - 6 of 6)
Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Title
Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author
Bose, Mukulika
Date Created
2022
Subjects--Topical
Molecular biology, Biochemistry, Oncology
Description
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...
Characterizing a New Regulator of the ATR Signaling Pathway
Title
Characterizing a New Regulator of the ATR Signaling Pathway
Author
Biller, Megan
Date Created
2022
Subjects--Topical
Molecular biology, Biology
Description
Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...
Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications
Title
Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications
Author
Truman, Andrew, Zheng, Bo, Omkar, Siddhi, Takakuwa, Jade E.
Date Created
2022
Subjects--Topical
Proteins, Molecular biology
Description
Hsp70 interactions are critical for cellular viability and the response to stress. Previous attempts to characterize Hsp70 interactions have been limited by their transient nature and the inability of current technologies to distinguish direct ver...
Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
Title
Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
Author
Noll, Braxton
Date Created
2022
Subjects--Topical
Molecular biology
Description
Primary Sjögren’s syndrome (pSS) is an autoimmune disease of exocrine tissues causing dry mouth and eyes, mainly affecting women. A culmination of etiologic events leads to the loss of epithelial homeostasis resulting in the MMP9-mediated destruct...
Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Title
Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Author
Kepple, Daniel
Date Created
2022
Subjects--Topical
Biology, Molecular biology, Cytology
Description
Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. P. vivax was previously thought to be rare or absent in Africa because people of African descent often lack the ...
Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Title
Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Author
Patton, David
Date Created
2022
Subjects--Topical
Bioinformatics, Molecular biology, Biometry
Description
Mutations play a pivotal role as a driver of genome evolution in organisms across the tree of life. However, site-specific mutation rates appear to have a non-uniform mutation rate and vary across the genome. Currently, site-specific variation has...