Search results | J. Murrey Atkins Library

Title: APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author: HOSSAIN, MD AKRAM
Date Created: 2021
Subjects--Topical: Molecular biology, Biology, Cytology
Description: The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...

Title: Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author: Bose, Mukulika
Date Created: 2022
Subjects--Topical: Molecular biology, Biochemistry, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...

Title: CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
Author: Sharma, Sunita
Date Created: 2019
Subjects--Topical: Molecular biology, Biology
Description: Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...

Title: CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Author: Patil, Sushant
Date Created: 2016
Subjects--Topical: Molecular biology, Bioinformatics, Biochemistry
Description: Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...

Title: Cell Type-Specific Double Strand Break Repair: An Inter-Chromosomal Homologous Recombination Study Using the Rainbow Mouse Model
Author: Lalwani, Kiran
Date Created: 2023
Subjects--Topical: Molecular biology, Cytology, Developmental biology
Description: Faithful repair of DNA lesions is central to maintaining genomic integrity. Illegitimate repair of chromosomal DNA damage, especially double-strand breaks (DSBs), can lead to mutations and genome rearrangements. Homologous recombination (HR) is a ...

Title: Characterizing a New Regulator of the ATR Signaling Pathway
Author: Biller, Megan
Date Created: 2022
Subjects--Topical: Molecular biology, Biology
Description: Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...

Title: Circadian behavior and gene expression in an estuarine cnidarian, Nematostella vectensis
Author: Leach, Whitney
Date Created: 2019
Subjects--Topical: Molecular biology, Ecology
Description: Animals respond to diurnal shifts in their environment with a combination of behavioral, physiological, and molecular changes to synchronize with regularly-timed external cues. The light:dark cycle is regarded as the most important entrainment cue...

Title: Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
Author: Vestal, Carol
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...

Title: Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
Author: Wang, Lin
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Genetics
Description: Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...

Title: Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications
Author: Truman, Andrew, Zheng, Bo, Omkar, Siddhi, Takakuwa, Jade E.
Date Created: 2022
Subjects--Topical: Proteins, Molecular biology
Description: Hsp70 interactions are critical for cellular viability and the response to stress. Previous attempts to characterize Hsp70 interactions have been limited by their transient nature and the inability of current technologies to distinguish direct ver...

Title: Dissecting The Salivary Gland: Epithelial-Centered Dysfunction in Primary Sjögren’s Syndrome
Author: Noll, Braxton
Date Created: 2022
Subjects--Topical: Molecular biology
Description: Primary Sjögren’s syndrome (pSS) is an autoimmune disease of exocrine tissues causing dry mouth and eyes, mainly affecting women. A culmination of etiologic events leads to the loss of epithelial homeostasis resulting in the MMP9-mediated destruct...

Title: EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author: Seegers, Sara
Date Created: 2019
Subjects--Topical: Molecular biology, Virology, Biology
Description: Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...

Title: Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Author: Kepple, Daniel
Date Created: 2022
Subjects--Topical: Biology, Molecular biology, Cytology
Description: Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. P. vivax was previously thought to be rare or absent in Africa because people of African descent often lack the ...

Title: Hepatic Stellate Cell Transdifferentiation: Pro-fibrogenic Effectors
Author: Lakner, Ashley
Date Created: 2011
Subjects--Topical: Molecular biology, Biology
Description: Hepatic fibrosis is a significant cause of morbidity and mortality worldwide and can be described as exacerbated wound-healing marked by excessive deposition of extracellular matrix components, predominantly type I collagen. Chronic injury stimula...

Title: Investigating the Molecular Mechanisms of Essential Oils on Human Health
Author: Uppal, Aneeta
Date Created: 2020
Subjects--Topical: Molecular biology, Bioinformatics, Botany
Description: The essential oil (EO) industry continues to grow as consumers search for more alternative and complementary therapies. When possible, EO users often turn to EOs for basic medical ailments instead of traditional medications/pharmaceuticals. With t...

Title: Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Author: Patton, David
Date Created: 2022
Subjects--Topical: Bioinformatics, Molecular biology, Biometry
Description: Mutations play a pivotal role as a driver of genome evolution in organisms across the tree of life. However, site-specific mutation rates appear to have a non-uniform mutation rate and vary across the genome. Currently, site-specific variation has...

Title: Loss of Skeletal Muscle PKC Theta Protects Against The Pathogenesis of Insulin Resistance
Author: Peck, Bailey
Date Created: 2016
Subjects--Topical: Molecular biology, Medical sciences
Description: Skeletal muscle is a primary regulator of glucose homeostasis, accounting for the majority of post-prandial glucose disposal. However states of skeletal muscle insulin-resistance result in severely attenuated glucose uptake and consequently hyperg...

Title: MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
Author: Felt, Sebastien
Date Created: 2017
Subjects--Topical: Molecular biology, Virology, Cytology
Description: Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...

Title: Molecular function recognition by supervised projection pursuit machine learning
Author: Jacobs, Donald J., Grear, Tyler, Avery, Chris, Patterson, John
Date Created: 2021
Subjects--Topical: Molecular biology, Pharmaceutical chemistry
Description: Identifying mechanisms that control molecular function is a significant challenge in pharmaceutical science and molecular engineering. Here, we present a novel projection pursuit recurrent neural network to identify functional mechanisms in the co...

Title: Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
Author: Lambirth, Kevin
Date Created: 2015
Subjects--Topical: Molecular biology, Biology, Bioinformatics
Description: The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...