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ACCURATE AND EFFICIENT CALCULATION OF SINGULAR ELECTROSTATIC POTENTIALS IN CHARGE-DIELECTRIC SPHERICAL AND JANUS PARTICLE SYSTEMS
Title
ACCURATE AND EFFICIENT CALCULATION OF SINGULAR ELECTROSTATIC POTENTIALS IN CHARGE-DIELECTRIC SPHERICAL AND JANUS PARTICLE SYSTEMS
Author
Retz, Caylah
Date Created
2018
Subjects--Topical
Molecular biology, Mathematics, Physics
Description
We introduce an efficient and accurate boundary element method for computing the electrostatic potential in closely-packed dielectric spheres and Janus particles. Close physical proximity occurs in modeling molecular ion interactions or colloidal ...
CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Title
CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Author
Patil, Sushant
Date Created
2016
Subjects--Topical
Molecular biology, Bioinformatics, Biochemistry
Description
Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...
Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications
Title
Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications
Author
Truman, Andrew, Zheng, Bo, Omkar, Siddhi, Takakuwa, Jade E.
Date Created
2022
Subjects--Topical
Proteins, Molecular biology
Description
Hsp70 interactions are critical for cellular viability and the response to stress. Previous attempts to characterize Hsp70 interactions have been limited by their transient nature and the inability of current technologies to distinguish direct ver...
Current perspectives of telomerase structure and function in eukaryotes with emerging views on telomerase in human parasites
Title
Current perspectives of telomerase structure and function in eukaryotes with emerging views on telomerase in human parasites
Author
Chakrabarti, Kausik, Dey, Abhishek
Date Created
2018
Subjects--Topical
Molecular biology, Evolution (Biology)
Description
Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant lengthening or reduction in the length of telomeres can lead to health anomalies, such as cancer or premature aging. Telomerase is a master regulator f...
Investigating the Molecular Mechanisms of Essential Oils on Human Health
Title
Investigating the Molecular Mechanisms of Essential Oils on Human Health
Author
Uppal, Aneeta
Date Created
2020
Subjects--Topical
Molecular biology, Bioinformatics, Botany
Description
The essential oil (EO) industry continues to grow as consumers search for more alternative and complementary therapies. When possible, EO users often turn to EOs for basic medical ailments instead of traditional medications/pharmaceuticals. With t...
Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Title
Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Author
Patton, David
Date Created
2022
Subjects--Topical
Bioinformatics, Molecular biology, Biometry
Description
Mutations play a pivotal role as a driver of genome evolution in organisms across the tree of life. However, site-specific mutation rates appear to have a non-uniform mutation rate and vary across the genome. Currently, site-specific variation has...
Loss of Skeletal Muscle PKC Theta Protects Against The Pathogenesis of Insulin Resistance
Title
Loss of Skeletal Muscle PKC Theta Protects Against The Pathogenesis of Insulin Resistance
Author
Peck, Bailey
Date Created
2016
Subjects--Topical
Molecular biology, Medical sciences
Description
Skeletal muscle is a primary regulator of glucose homeostasis, accounting for the majority of post-prandial glucose disposal. However states of skeletal muscle insulin-resistance result in severely attenuated glucose uptake and consequently hyperg...
Molecular function recognition by supervised projection pursuit machine learning
Title
Molecular function recognition by supervised projection pursuit machine learning
Author
Jacobs, Donald J., Grear, Tyler, Avery, Chris, Patterson, John
Date Created
2021
Subjects--Topical
Molecular biology, Pharmaceutical chemistry
Description
Identifying mechanisms that control molecular function is a significant challenge in pharmaceutical science and molecular engineering. Here, we present a novel projection pursuit recurrent neural network to identify functional mechanisms in the co...