Search results
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Title
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Cytosolic DNA sensors and CNS responses to viral pathogens
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Author
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Marriott, Ian, Jeffries, Austin
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Subjects--Topical
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DNA, Virus diseases
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Description
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Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
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Title
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Cytosolic DNA sensors and glial responses to endogenous DNA
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Author
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Marriott, Ian, Suptela, Alexander J.
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Date Created
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2023
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Subjects--Topical
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Genomics, DNA
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Description
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Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
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Title
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Modeling of ssDNA binding protein structures
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Author
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Jariwala, Maanav, Guo, Jun-tao
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Date Created
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2022
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Subjects--Topical
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DNA, Protein binding
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Description
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Single-stranded DNA (ssDNA) binding proteins are crucial for biological processes including replication, transcription, and genomic integrity. We can better comprehend the function of the proteins and their interactions with ssDNA with structures ...
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Title
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PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
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Author
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Yan, Chenbo
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Date Created
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2020
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Subjects--Topical
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Biophysics, DNA
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Description
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Due to the substantial interest in developing transposon technology for gene delivery and gene therapy, the Sleeping Beauty (SB) transposon system, the most active transposon in the vertebrate species, has been extensively studied. The SB transpos...