Search results
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Title
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APE2 promotes DNA damage response pathway from a single-strand break
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Author
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Yan, Shan, Lin, Yunfeng, Bai, Liping, Cupello, Steven
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Date Created
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2018
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Subjects--Topical
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Cancer--Research, DNA
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Description
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As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurod...
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Title
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Modeling of ssDNA binding protein structures
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Author
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Jariwala, Maanav, Guo, Jun-tao
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Date Created
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2022
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Subjects--Topical
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DNA, Protein binding
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Description
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Single-stranded DNA (ssDNA) binding proteins are crucial for biological processes including replication, transcription, and genomic integrity. We can better comprehend the function of the proteins and their interactions with ssDNA with structures ...
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Title
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PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
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Author
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Yan, Chenbo
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Date Created
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2020
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Subjects--Topical
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Biophysics, DNA
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Description
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Due to the substantial interest in developing transposon technology for gene delivery and gene therapy, the Sleeping Beauty (SB) transposon system, the most active transposon in the vertebrate species, has been extensively studied. The SB transpos...