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APE2 promotes DNA damage response pathway from a single-strand break
Title
APE2 promotes DNA damage response pathway from a single-strand break
Author
Yan, Shan, Lin, Yunfeng, Bai, Liping, Cupello, Steven
Date Created
2018
Subjects--Topical
Cancer--Research, DNA
Description
As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurod...
ComparePD : improving protein–DNA complex model comparison with hydrogen bond energy-based metrics
Title
ComparePD : improving protein–DNA complex model comparison with hydrogen bond energy-based metrics
Author
Guo, Jun-tao, Malik, Fareeha Kanwal
Date Created
2023
Subjects--Topical
DNA, Nucleic acids
Description
Computational modeling of protein–DNA complex structures has important implications in biomedical applications such as structure-based, computer aided drug design. A key step in developing methods for accurate modeling of protein–DNA complexes is ...
Cytosolic DNA sensors and CNS responses to viral pathogens
Title
Cytosolic DNA sensors and CNS responses to viral pathogens
Author
Marriott, Ian, Jeffries, Austin
Subjects--Topical
DNA, Virus diseases
Description
Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
Cytosolic DNA sensors and glial responses to endogenous DNA
Title
Cytosolic DNA sensors and glial responses to endogenous DNA
Author
Marriott, Ian, Suptela, Alexander J.
Date Created
2023
Subjects--Topical
Genomics, DNA
Description
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
Modeling of ssDNA binding protein structures
Title
Modeling of ssDNA binding protein structures
Author
Jariwala, Maanav, Guo, Jun-tao
Date Created
2022
Subjects--Topical
DNA, Protein binding
Description
Single-stranded DNA (ssDNA) binding proteins are crucial for biological processes including replication, transcription, and genomic integrity. We can better comprehend the function of the proteins and their interactions with ssDNA with structures ...
PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
Title
PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
Author
Yan, Chenbo
Date Created
2020
Subjects--Topical
Biophysics, DNA
Description
Due to the substantial interest in developing transposon technology for gene delivery and gene therapy, the Sleeping Beauty (SB) transposon system, the most active transposon in the vertebrate species, has been extensively studied. The SB transpos...
Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Title
Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Author
Marriott, Ian, Jeffries, Austin M., Suptela, Alexander J.
Date Created
2022
Subjects--Topical
Herpes simplex virus, DNA
Description
The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition receptors that include intracellular RNA an...