Search results
- Title
- COMPLEX ADAPTIVE SYSTEMS AND THE THRESHOLD EFFECT: TOWARDS A GENERAL TOOL FOR STUDYING DYNAMIC PHENOMENA ACROSS DIVERSE DOMAINS
- Author
- Carmichael, Theodore
- Date Created
- 2010
- Subjects--Topical
- Computer science, Social structure, Cytology
- Description
- Most interesting phenomena in natural and social systems include transitions and oscillations among their various phases. A new phase begins when the system reaches a threshold that marks a qualitative change in system characteristics. These thres...
- Title
- Cell Type-Specific Double Strand Break Repair: An Inter-Chromosomal Homologous Recombination Study Using the Rainbow Mouse Model
- Author
- Lalwani, Kiran
- Date Created
- 2023
- Subjects--Topical
- Molecular biology, Cytology, Developmental biology
- Description
- Faithful repair of DNA lesions is central to maintaining genomic integrity. Illegitimate repair of chromosomal DNA damage, especially double-strand breaks (DSBs), can lead to mutations and genome rearrangements. Homologous recombination (HR) is a ...
- Title
- FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
- Author
- Ke, Weina
- Date Created
- 2020
- Subjects--Topical
- Biochemistry, Cytology
- Description
- Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...
- Title
- High-order integral equations for electromagnetic problems in layered media with applications in biology and solar cells
- Author
- Zinser, Brian
- Date Created
- 2016
- Subjects--Topical
- Mathematics, Cytology, Electromagnetism
- Description
- We present two distinct mathematical models where high-order integral equations are applied to electromagnetic problems. The first problem is to find the electric potential in and around ion channels and Janus particles. The second problem is to f...
- Title
- Interaction between hydrogen sulfide and endothelin-1 in hepatic perfusion and mitochondrial dynamics in endotoxemia
- Author
- Pennington, Samantha
- Date Created
- 2018
- Subjects--Topical
- Physiology, Cytology
- Description
- A mismatch between oxygen supply and metabolic tissue demand leads to the development of hypoxia, which contributes to hepatic dysfunction and liver injury during sepsis. Recent evidence shows that hepatic H2S levels are increased during sepsis an...
- Title
- Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens
- Author
- Sterka, David
- Date Created
- 2009
- Subjects--Topical
- Cytology
- Description
- There is growing appreciation that the resident glial cells of the CNS, in particular microglia and astrocytes, are important participants in the generation of inflammation during brain infection. However, the mechanisms by which these cell types ...
- Title
- MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
- Author
- Felt, Sebastien
- Date Created
- 2017
- Subjects--Topical
- Molecular biology, Virology, Cytology
- Description
- Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...
- Title
- Polystyrene particle uptake and their potential to act as a trojan horse to oysters (Crassostrea virginica)
- Author
- Gaspar, Tamara
- Date Created
- 2017
- Subjects--Topical
- Environmental sciences, Ecology, Cytology
- Description
- The global annual usage of plastics has increased dramatically over the last decade. Polystyrene is the fourth most common plastic material produced annually due to its many versatile applications. Consequently, there has been a coinciding increas...
- Title
- REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
- Author
- Ha, Anh
- Date Created
- 2020
- Subjects--Topical
- Molecular biology, Cytology
- Description
- Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...
- Title
- ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
- Author
- Mattocks, Matthew
- Date Created
- 2010
- Subjects--Topical
- Molecular biology, Cytology, Oncology
- Description
- Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...
- Title
- Regulation of Myosin IIIa Motor/Kinase Activity
- Author
- Moore, Judy
- Date Created
- 2009
- Subjects--Topical
- Biochemistry, Neurosciences, Cytology
- Description
- Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...
- Title
- SNARE Protein Evolution and Expansion Drives Endosome Complexity
- Author
- Grissom, James
- Date Created
- 2023
- Subjects--Topical
- Cytology, Evolutionary developmental biology
- Description
- The budding yeast Saccharomyces cerevisiae is a powerful and well-studied model organism that is responsible for much of our understanding in the fields of endocytosis, the secretory pathway, and membrane trafficking. Traditionally, it was thought...
- Title
- Sexual Dimorphism in Sepsis Susceptibility: Effects of Reproductive Hormones on Pattern Recognition Receptor Expression
- Author
- Rettew, Jennifer
- Date Created
- 2010
- Subjects--Topical
- Cytology
- Description
- Sex-based differences in innate immune responses to bacterial infection are evident in human patients and animal models of disease. Females are less susceptible to the development of bacterial infections and subsequent bacteremia and/or sepsis whi...
- Title
- TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
- Author
- Nath, Sritama
- Date Created
- 2013
- Subjects--Topical
- Molecular biology, Cytology, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US. An understanding of the molecular pathogenesis of PDA is of utmost importance to be able to improve the current or design new targeted therapies fo...
- Title
- Understanding Chaperone interactions in disease
- Author
- Nitika
- Date Created
- 2021
- Subjects--Topical
- Molecular biology, Biochemistry, Cytology
- Description
- The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...
- Title
- VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
- Author
- goyal, Shreya
- Date Created
- 2021
- Subjects--Topical
- Biochemistry, Cytology, Molecular biology
- Description
- ABSTRACTCareful control of intracellular signaling pathways plays an important role in a cell’s ability to maintain stable internal conditions in the face of an ever-changing extracellular environment. This is particularly true as it relates to th...