Search results | J. Murrey Atkins Library

Title: A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
Author: Taylor, Jonathon
Date Created: 2020
Subjects--Topical: Biology, Cytology, Evolutionary developmental biology
Description: There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...

Title: APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author: HOSSAIN, MD AKRAM
Date Created: 2021
Subjects--Topical: Molecular biology, Biology, Cytology
Description: The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...

Title: COMPLEX ADAPTIVE SYSTEMS AND THE THRESHOLD EFFECT: TOWARDS A GENERAL TOOL FOR STUDYING DYNAMIC PHENOMENA ACROSS DIVERSE DOMAINS
Author: Carmichael, Theodore
Date Created: 2010
Subjects--Topical: Computer science, Social structure, Cytology
Description: Most interesting phenomena in natural and social systems include transitions and oscillations among their various phases. A new phase begins when the system reaches a threshold that marks a qualitative change in system characteristics. These thres...

Title: EFFECTS OF S-ADENOSYL-L-METHIONINE ON COLLAGEN EXPRESSION IN ACTIVATED HEPATIC STELLATE CELLS
Author: Thompson, Kyle
Date Created: 2009
Subjects--Topical: Biology, Cytology
Description: Liver fibrosis is defined as the excessive accumulation of extracellular matrix (ECM) components, which can disrupt the normal liver microcirculation and lead to injury. Unresolved, hepatic fibrosis can progress to cirrhosis, an end-state liver di...

Title: FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
Author: Ke, Weina
Date Created: 2020
Subjects--Topical: Biochemistry, Cytology
Description: Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...

Title: High-order integral equations for electromagnetic problems in layered media with applications in biology and solar cells
Author: Zinser, Brian
Date Created: 2016
Subjects--Topical: Mathematics, Cytology, Electromagnetism
Description: We present two distinct mathematical models where high-order integral equations are applied to electromagnetic problems. The first problem is to find the electric potential in and around ion channels and Janus particles. The second problem is to f...

Title: Interaction between hydrogen sulfide and endothelin-1 in hepatic perfusion and mitochondrial dynamics in endotoxemia
Author: Pennington, Samantha
Date Created: 2018
Subjects--Topical: Physiology, Cytology
Description: A mismatch between oxygen supply and metabolic tissue demand leads to the development of hypoxia, which contributes to hepatic dysfunction and liver injury during sepsis. Recent evidence shows that hepatic H2S levels are increased during sepsis an...

Title: Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens
Author: Sterka, David
Date Created: 2009
Subjects--Topical: Cytology
Description: There is growing appreciation that the resident glial cells of the CNS, in particular microglia and astrocytes, are important participants in the generation of inflammation during brain infection. However, the mechanisms by which these cell types ...

Title: MOLECULAR MECHANISMS OF RESISTANCE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS TO ONCOLYTIC VESICULAR STOMATITIS VIRUS
Author: Felt, Sebastien
Date Created: 2017
Subjects--Topical: Molecular biology, Virology, Cytology
Description: Oncolytic virus (OV) therapy is an anticancer therapy using replication-competent viruses selectively infecting, replicating in and killing cancer cells. Human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their pe...

Title: Periostin and TGFBI in Breast Cancer Progression
Author: Phelps, Michelle
Date Created: 2015
Subjects--Topical: Biology, Cytology
Description: Dynamic interactions between cancer cells, supportive stromal cells, the extracellular matrix (ECM), and the immune system are critical to breast cancer progression. Periostin is an ECM protein correlated to poor outcomes in breast cancer. Periost...

Title: Polystyrene particle uptake and their potential to act as a trojan horse to oysters (Crassostrea virginica)
Author: Gaspar, Tamara
Date Created: 2017
Subjects--Topical: Environmental sciences, Ecology, Cytology
Description: The global annual usage of plastics has increased dramatically over the last decade. Polystyrene is the fourth most common plastic material produced annually due to its many versatile applications. Consequently, there has been a coinciding increas...

Title: REGULATION OF APE1 BY NEIL3 ZINC FINGER-GRF REPEAT ON SINGLE-STRANDED DNA
Author: Ha, Anh
Date Created: 2020
Subjects--Topical: Molecular biology, Cytology
Description: Base excision repair (BER) is a critical pathway in repairing single base lesions caused by oxidation, deamination, and alkylation. NEIL3 is a DNA glycosylase which functions in initiating BER pathway by recognizing and removing damaged bases. Alt...

Title: ROLE OF AQUAPORINS DURING HEPATOCELLULAR CARCINOMA INITIATION AND PROGRESSION
Author: Mattocks, Matthew
Date Created: 2010
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Aquaporins (AQPs) are ubiquitously expressed proteinaceous water channels involved in numerous physiological processes including bile production and apoptosis. Aquaporins 8 and 9 are expressed in hepatocytes, and are down regulated in a rat model ...

Title: Regulation of Myosin IIIa Motor/Kinase Activity
Author: Moore, Judy
Date Created: 2009
Subjects--Topical: Biochemistry, Neurosciences, Cytology
Description: Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...

Title: Sexual Dimorphism in Sepsis Susceptibility: Effects of Reproductive Hormones on Pattern Recognition Receptor Expression
Author: Rettew, Jennifer
Date Created: 2010
Subjects--Topical: Cytology
Description: Sex-based differences in innate immune responses to bacterial infection are evident in human patients and animal models of disease. Females are less susceptible to the development of bacterial infections and subsequent bacteremia and/or sepsis whi...

Title: THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
Author: McLeod, Melissa
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...

Title: THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
Author: Cupello, Steven
Date Created: 2019
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...

Title: TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
Author: Nath, Sritama
Date Created: 2013
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US. An understanding of the molecular pathogenesis of PDA is of utmost importance to be able to improve the current or design new targeted therapies fo...

Title: Understanding Chaperone interactions in disease
Author: Nitika
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Cytology
Description: The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...

Title: Understanding Chaperone interactions in disease
Author: ., Nitika
Date Created: 2021
Subjects--Topical: Biochemistry, Molecular biology, Cytology
Description: The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...