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Chemical Tools for Biology
Title
Chemical Tools for Biology
Author
Fessler, Adam
Date Created
2017
Subjects--Topical
Chemistry
Description
Reagents for biotinylation that are innately water-soluble and can be tracked by both UV-vis spectroscopy and fluorescence (330nm/420nm) have been developed. These reagents are based on the isatoic anhydride platform, which gives rise to their val...
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Title
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Author
Fessler, Adam
Date Created
2021
Subjects--Topical
Chemistry, Biology
Description
The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...
Exceptional New Reagents for Bioconjugation
Title
Exceptional New Reagents for Bioconjugation
Author
Garmon, Corey
Date Created
2016
Subjects--Topical
Chemistry, Biochemistry
Description
At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...