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Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
Title
Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
Author
Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
Subjects--Topical
Cancer, Viruses
Description
Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...
Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Title
Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Author
Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
Subjects--Topical
Cancer, Gene therapy
Description
Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...
Dysregulation of AKT3 along with a small panel of mRNAs stratifies high-grade serous ovarian cancer from both normal epithelia and benign tumor tissues
Title
Dysregulation of AKT3 along with a small panel of mRNAs stratifies high-grade serous ovarian cancer from both normal epithelia and benign tumor tissues
Author
Yeganeh, Pourya Naderi, Richardson, Christine, Mostafavi, M. Taghi, Bahrani-Mostafavi, Zahra
Date Created
2017
Subjects--Topical
Cancer, Ovaries--Cancer
Description
Screening methods of High-Grade Serous Ovarian Cancer (HGSOC) lack specificity and sensitivity, partly due to benign tumors producing false-positive findings. We utilized a differential expression analysis pipeline on malignant tumor (MT) and norm...
Mesoporous silica nanoparticles loaded with cisplatin and phthalocyanine for combination chemotherapy and photodynamic therapy in vitro
Title
Mesoporous silica nanoparticles loaded with cisplatin and phthalocyanine for combination chemotherapy and photodynamic therapy in vitro
Author
Vivero-Escoto, Juan, Elnagheeb, Maram
Subjects--Topical
Chemotherapy, Cancer
Description
Mesoporous silica nanoparticles (MSNs) have been synthesized and loaded with both aluminum chloride phthalocyanine (AlClPc) and cisplatin as combinatorial therapeutics for treating cancer. The structural and photophysical properties of the MSN mat...
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Title
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author
Grdzelishvili, Valery, Hastie, Eric Lawrence, Cataldi, Marcela, Moerdyk-Schauwecker, Megan J., Felt, Sebastien A., Steuerwald, Nury
Subjects--Topical
Cancer, Viruses
Description
Vesicular stomatitis virus (VSV) based recombinant viruses (such as VSV-ΔM51) are effective oncolytic viruses (OVs) against a majority of pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to VSV...