Search results
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Title
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DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
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Author
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Baker, Lonnie
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Date Created
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2020
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Subjects--Topical
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Bioinformatics, Biophysics
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Description
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Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the destruction of foreign antigens do not randomly target molecules but rely on...
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Title
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ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
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Author
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Singer, Christopher
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Date Created
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2019
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Subjects--Topical
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Bioinformatics, Biophysics, Physics
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Description
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Protein thermodynamics has been shown to be insightful and illuminating to the functional mechanisms behind biological function. By characterizing proteins and protein families according to their enthalpy and entropy we can make inferences to the ...
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Title
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ESSENTIAL DYNAMICS OF PROTEINS USING GEOMETRICAL SIMULATIONS AND SUBSPACE ANALYSIS
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Author
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David, Charles
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Date Created
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2012
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Subjects--Topical
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Physics, Bioinformatics, Biophysics
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Description
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Essential dynamics is the application of principal component analysis to a dynamic trajectory derived from a simulation protocol in order to extract biologically relevant information contained in the high dimensional data. In this work, we apply t...
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Title
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Functional Dynamics in Beta-Lactamase: Insights into Substrate Recognition and Inhibition
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Author
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Avery, Christopher
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Date Created
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2023
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Subjects--Topical
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Bioinformatics, Biophysics, Physics
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Description
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Beta-lactamase proteins are among the most prominent causes of antibiotic resistance. These enzymes confer resistance to beta lactam antibiotics, which are commonly used to treat bacterial infections. In recent years, novel beta-lactamase have eme...
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Title
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THE EFFECT OF TARGET SECONDARY STRUCTURE ON MICROARRAY DATA QUALITY
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Author
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Ratushna, Vladyslava
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Date Created
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2010
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Subjects--Topical
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Bioinformatics, Biophysics
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Description
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DNA microarrays have become an invaluable high throughput biotechnology method, which allows a parallel investigation of thousands of cellular events in a single experiment. The principle behind the technology is very simple: fluorescently labeled...
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Title
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THERMODYNAMIC AND MECHANICAL EFFECTS OF DISULFIDE BONDS IN CXCL7 CHEMOKINE
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Author
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Singer, Christopher
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Date Created
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2015
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Subjects--Topical
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Physics, Bioinformatics, Biophysics
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Description
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Chemokines are a family of signaling proteins mainly responsible for the chemotaxis of leukocytes, where their biological activity is modulated by their oligomerization state. Here, the dynamics and thermodynamic stability are characterized in mon...
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Title
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UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
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Author
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Price, Adam
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Date Created
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2017
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Subjects--Topical
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Biology, Bioinformatics, Biophysics
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Description
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The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...
