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DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Title
DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
Author
Baker, Lonnie
Date Created
2020
Subjects--Topical
Bioinformatics, Biophysics
Description
Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the destruction of foreign antigens do not randomly target molecules but rely on...
Elucidating Dynamic Mechanisms for Extended Spectrum Antibiotic Resistance in Class A Beta-Lactamase through Machine Learning on Molecular Dynamics Simulations
Title
Elucidating Dynamic Mechanisms for Extended Spectrum Antibiotic Resistance in Class A Beta-Lactamase through Machine Learning on Molecular Dynamics Simulations
Author
Avery, Christopher
Date Created
2019
Subjects--Topical
Biophysics, Physics
Description
Beta-lactamase is a protein which is produced in bacteria and is a primary cause of antibiotic resistance to Beta Lactam antibiotics. Beta Lactams are among the most common types of antibiotics (including penicillin) and thus understanding the res...
PREPARATION AND VISUALIZATION OF INDIVIDUAL ACTIN FILAMENTS USING ATOMIC FORCE MICROSCOPY FOR THE STUDY OF ACTIN/DNA HYDROGEL COMPLEXES
Title
PREPARATION AND VISUALIZATION OF INDIVIDUAL ACTIN FILAMENTS USING ATOMIC FORCE MICROSCOPY FOR THE STUDY OF ACTIN/DNA HYDROGEL COMPLEXES
Author
Kennedy, Joshua
Date Created
2019
Subjects--Topical
Physics, Biophysics, Biomedical engineering
Description
A protocol of sample preparation for the visualization of single actin filaments at the nanoscale using atomic force microscopy for use in studies of engineered actin/DNA conjugated hydrogel complexes was developed. Hydrogels are cross-linked netw...
PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
Title
PROTEIN-PROTEIN INTERACTION OF PAI-H19Y MUTANT OF THE SLEEPING BEAUTY TRANSPOSASE
Author
Yan, Chenbo
Date Created
2020
Subjects--Topical
Biophysics, DNA
Description
Due to the substantial interest in developing transposon technology for gene delivery and gene therapy, the Sleeping Beauty (SB) transposon system, the most active transposon in the vertebrate species, has been extensively studied. The SB transpos...
STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE H19Y MUTATED PRIMARY DNA RECOGNITION SUBDOMAIN OF SLEEPING BEAUTY TRANSPOSASE
Title
STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE H19Y MUTATED PRIMARY DNA RECOGNITION SUBDOMAIN OF SLEEPING BEAUTY TRANSPOSASE
Author
Leighton, Gage
Date Created
2017
Subjects--Topical
Physics, Chemistry, Physical and theoretical, Biophysics
Description
The Sleeping Beauty transposon system, consisting of the transposon DNA and the transposase enzyme, is a member of the Tc1/mariner family of DNA transposons. Although it is an important tool in genetic applications and has been adapted for human g...
THERMODYNAMIC AND MECHANICAL EFFECTS OF DISULFIDE BONDS IN CXCL7 CHEMOKINE
Title
THERMODYNAMIC AND MECHANICAL EFFECTS OF DISULFIDE BONDS IN CXCL7 CHEMOKINE
Author
Singer, Christopher
Date Created
2015
Subjects--Topical
Physics, Bioinformatics, Biophysics
Description
Chemokines are a family of signaling proteins mainly responsible for the chemotaxis of leukocytes, where their biological activity is modulated by their oligomerization state. Here, the dynamics and thermodynamic stability are characterized in mon...
Volume Microenvironment Self-Consistent Constraint Theory Applied to Protein Stability Prediction
Title
Volume Microenvironment Self-Consistent Constraint Theory Applied to Protein Stability Prediction
Author
Johannessen, Nicholas
Date Created
2021
Subjects--Topical
Biophysics, Physics
Description
Controlling thermodynamic stability is a challenge in protein engineering. Engineering a protein by introducing mutations into its sequence to increase efficacy can destabilize the protein thermodynamically, preventing it from functioning in its i...