Search results
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Title
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ELUCIDATING FUNCTIONAL MECHANISMS IN PROTEINS USING THE DISTANCE CONSTRAINT MODEL
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Author
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Singer, Christopher
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Date Created
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2019
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Subjects--Topical
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Bioinformatics, Biophysics, Physics
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Description
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Protein thermodynamics has been shown to be insightful and illuminating to the functional mechanisms behind biological function. By characterizing proteins and protein families according to their enthalpy and entropy we can make inferences to the ...
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Title
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ESSENTIAL DYNAMICS OF PROTEINS USING GEOMETRICAL SIMULATIONS AND SUBSPACE ANALYSIS
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Author
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David, Charles
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Date Created
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2012
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Subjects--Topical
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Physics, Bioinformatics, Biophysics
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Description
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Essential dynamics is the application of principal component analysis to a dynamic trajectory derived from a simulation protocol in order to extract biologically relevant information contained in the high dimensional data. In this work, we apply t...
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Title
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Functional Dynamics in Beta-Lactamase: Insights into Substrate Recognition and Inhibition
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Author
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Avery, Christopher
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Date Created
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2023
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Subjects--Topical
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Bioinformatics, Biophysics, Physics
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Description
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Beta-lactamase proteins are among the most prominent causes of antibiotic resistance. These enzymes confer resistance to beta lactam antibiotics, which are commonly used to treat bacterial infections. In recent years, novel beta-lactamase have eme...
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Title
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REGULATION OF ACTOMYOSIN ATPASE
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Author
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Ge, Jinghua
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Date Created
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2016
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Subjects--Topical
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Optics, Physics, Biophysics
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Description
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Myosin is a molecular motor that converts chemical energy to mechanical energy, thus generating force and movement in muscles and cells. Myosin interacts with two ligands, ATP (fuel) and actin filaments (motor’s tracks). Actomyosin interaction is ...
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Title
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SUBSURFACE THERMAL COAGULATION OF TISSUES USING NEAR INFRARED LASERS
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Author
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Chang, Chun-Hung
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Date Created
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2017
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Subjects--Topical
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Optics, Biophysics, Biomedical engineering
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Description
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Noninvasive laser therapy is currently limited primarily to cosmetic dermatological applications such as skin resurfacing, hair removal, tattoo removal and treatment of vascular birthmarks. In order to expand applications of noninvasive laser ther...
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Title
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THE EFFECT OF TARGET SECONDARY STRUCTURE ON MICROARRAY DATA QUALITY
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Author
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Ratushna, Vladyslava
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Date Created
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2010
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Subjects--Topical
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Bioinformatics, Biophysics
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Description
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DNA microarrays have become an invaluable high throughput biotechnology method, which allows a parallel investigation of thousands of cellular events in a single experiment. The principle behind the technology is very simple: fluorescently labeled...
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Title
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UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
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Author
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Price, Adam
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Date Created
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2017
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Subjects--Topical
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Biology, Bioinformatics, Biophysics
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Description
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The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...