Search results
- Title
- EFFECT OF CADMIUM AND SEASONALITY ON CRITICAL TEMPERATURES OF AEROBIC METABOLISM IN EASTERN OYSTERS, Crassostrea virginica Gmelin 1791
- Author
- Bagwe, Rita
- Date Created
- 2012
- Subjects--Topical
- Biology
- Description
- Cadmium (Cd) and elevated temperatures are common stressors in estuarine and coastal environments affecting intertidal mollusks such as oysters. Cd and elevated temperature can raise the metabolic demands of oysters due to the increase cost of det...
- Title
- EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
- Author
- Seegers, Sara
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Virology, Biology
- Description
- Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
- Title
- RECIPROCAL REGULATION OF MYC AND MICRORNA MIR-308 DURING DROSOPHILA EMBRYOGENESIS
- Author
- Daneshvar, Kaveh
- Date Created
- 2012
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Myc is a conserved transcription factor with a role in the regulation of genes that are involved in growth and development. The abundance of Myc protein in the cells must be exquisitely controlled to avoid growth abnormalities caused by too much o...
- Title
- Cranial Capacity Variation of Pleistocene Homo and Possible Speciation Events
- Author
- Hudock, Autumn
- Date Created
- 2021
- Subjects--Topical
- Biology, Paleontology, Evolutionary developmental biology
- Description
- The field of paleoanthropology is tasked with studying the morphology of extinct hominins using fossilized remains. To study the evolution of the human brain, researchers use endocast data derived from fossil skulls, in order to assess when and ho...
- Title
- Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
- Author
- Fessler, Adam
- Date Created
- 2021
- Subjects--Topical
- Chemistry, Biology
- Description
- The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...
- Title
- Disulfide-trapped CXCL12-CXCL4 Chemokine Heterodimers Prevent Breast Cancer Progression
- Author
- Nguyen, Khanh
- Date Created
- 2021
- Subjects--Topical
- Biology
- Description
- Triple negative breast cancers (TNBCs), i.e., 10-15% of diagnosed breast cancers, have a triple negative (Her/2-, ER- and PR-) phenotype and are the most aggressive subtype of breast cancer. TNBCs have a worst prognosis because of the high probabi...
- Title
- Periostin and TGFBI in Breast Cancer Progression
- Author
- Phelps, Michelle
- Date Created
- 2015
- Subjects--Topical
- Biology, Cytology
- Description
- Dynamic interactions between cancer cells, supportive stromal cells, the extracellular matrix (ECM), and the immune system are critical to breast cancer progression. Periostin is an ECM protein correlated to poor outcomes in breast cancer. Periost...
- Title
- Polymer Mediated Delivery of Oligonucleotide and Trans Genes Toward More Efficient and Specific Therapies for Dystrophinopathies and Dystroglycanopathies
- Author
- Tucker, Jason
- Date Created
- 2014
- Subjects--Topical
- Molecular biology, Biology, Neurosciences
- Description
- Muscular dystrophies are genetic disorders caused by mutations in more than 30 genes, with no cure or effective treatment. Duchenne muscular dystrophy (DMD) is caused by frame-shift mutations in the dystrophin gene with little or no functional dys...
- Title
- Pleiotropic effects on the transcriptome and genome of transgenic soybeans resulting from transgene integration and expression in seed tissue
- Author
- Lambirth, Kevin
- Date Created
- 2015
- Subjects--Topical
- Molecular biology, Biology, Bioinformatics
- Description
- The seeds of the common soybean (Glycine max) produce and store large amounts of protein, making them an appealing bioreactor for producing valuable recombinant proteins at high levels. However, the effects of accumulating recombinant protein at h...
- Title
- RECONSTRUCTING AFRICA'S EVOLUTIONARY HISTORIES: DNA COLLECTION, CODING, ANALYSIS, and INTERPRETATION
- Author
- Winful, Olawunmi
- Date Created
- 2018
- Subjects--Topical
- Biology, Area studies, History
- Description
- Finding a way to successfully interpret African diversity is important in accurately reconstructing the evolutionary history of our species. By collecting high quality DNA, genealogical, and demographic data on a large cross section of African and...
- Title
- The Local Dynamics of Basement Membrane Breaching During Cancer Cell Invasion
- Author
- Nazari, Shayan
- Date Created
- 2022
- Subjects--Topical
- Biology
- Description
- Solid tumor metastasis is the leading cause of cancer-related mortality. Cancer invasion through the confining basement membrane (BM) is the initial step in tumor dissemination and metastasis, and it represents a key diagnostic feature of cancer. ...
- Title
- ASSESSING COMPARATIVE FUNCTIONS FOR THE BZIP TRANSCRIPTION FACTOR NFE2 IN NEMATOSTELLA VECTENSIS
- Author
- Clegg, Devin
- Date Created
- 2020
- Subjects--Topical
- Biology
- Description
- The bZIP gene superfamily is a family of transcription factors that have gone through multiple duplication events within bilaterians, specifically in vertebrates. This has led to multiple paralogs in each bZIP family while early diverging phyla ha...
- Title
- Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
- Author
- Wang, Lin
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...
- Title
- COMPARATIVE ANALYSIS OF REPEAT LANDSCAPES IN AVENA (OAT)
- Author
- Burkes, Shelvasha
- Date Created
- 2020
- Subjects--Topical
- Biology, Bioinformatics, Botany
- Description
- Avena sativa, or common oat, is a staple crop and member of the Poaceae or Grass family. Following behind wheat, maize and rice, oats account for 10.5 million hectares of the world’s produced crops as of 2017. Phytocompounds such as β-glucan, aven...
- Title
- The induction of type-I interferon responses in primary osteoblasts following staphylococcus aureus infection
- Author
- Furr, Kelli
- Date Created
- 2022
- Subjects--Topical
- Biology
- Description
- Osteomyelitis is a serious bacterial infection of bone that is associated with progressive inflammatory tissue damage. This condition commonly affects the long bones of children along with the vertebrae and pelvis of adults. Staphylococcus aureus,...
- Title
- Assessing the impact of temperature on population-specific gene expression of a model estuarine cnidarian, Nematostella vectensis
- Author
- Klock, Amy
- Date Created
- 2020
- Subjects--Topical
- Biology
- Description
- Temperature is a critical environmental factor that affects all living organisms. Climate change is resulting in rising global temperatures with marine environments being especially vulnerable. My study aimed to elucidate the temperature-dependent...
- Title
- BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
- Author
- GHOSH, ANINDITA
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...
- Title
- ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
- Author
- Farrel, Alvin
- Date Created
- 2016
- Subjects--Topical
- Computer science, Biology, Bioinformatics
- Description
- Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...
- Title
- Apoptotic T-cell derived microparticles containing sonic hedgehog modulate endothelial cell functions in inflammation via rho kinase pathway
- Author
- Attal, Neha
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Impaired vascular regulation as a result of endothelial dysfunction is a major determinant of sepsis-associated liver failure. We have previously shown that inhibition of one signaling molecule rho-kinase (ROCK) predominantly restores endothelial ...
- Title
- ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
- Author
- Okwei, Elleansar
- Date Created
- 2016
- Subjects--Topical
- Chemistry, Biology, Biochemistry
- Description
- The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...