Search results

  • CSV Spreadsheet
  • RSS Feed
(1 - 5 of 5)
EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Title
EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author
Seegers, Sara
Date Created
2019
Subjects--Topical
Molecular biology, Virology, Biology
Description
Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...
NOVEL ROLES OF MICRORNAS IN HEPATITIS C
Title
NOVEL ROLES OF MICRORNAS IN HEPATITIS C
Author
Sendi, Hossein
Date Created
2013
Subjects--Topical
Virology, Biology
Description
Approximately, 170 million people are infected by hepatitis C virus (HCV) worldwide, and of these, nearly 85% will develop chronic hepatitis C (CHC). Despite finding new anti-viral treatment that increase response rate from 45 % to 65-70 %, invest...
Nonsegmented negative strand RNA viruses: viral RNA cap methylation and potential applications as an anticancer therapy
Title
Nonsegmented negative strand RNA viruses: viral RNA cap methylation and potential applications as an anticancer therapy
Author
Murphy, Andrea
Date Created
2012
Subjects--Topical
Virology, Biology
Description
The viruses of the order Mononegavirales include important human, animal, and plant pathogens and additionally, have great potential as vaccine, oncolytic and gene therapy vectors. This dissertation focuses on two prototypic Mononegavirales, vesic...
Understanding The Role of Pancreatic Ductal Adenocarcinoma Chemoresistance and Intertumoral Heterogeneity on Vesicular Stomatitis Virus-based Oncolytic Therapy
Title
Understanding The Role of Pancreatic Ductal Adenocarcinoma Chemoresistance and Intertumoral Heterogeneity on Vesicular Stomatitis Virus-based Oncolytic Therapy
Author
Goad, Dakota
Date Created
2023
Subjects--Topical
Biology, Virology, Biomedical engineering
Description
Viruses are obligate intracellular parasites that are now being increasingly harnessed as therapeutics for human diseases. Investigating different cellular factors and processes that affect viral infection allows us to improve the efficacy of viru...
Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Title
Understanding and overcoming limitations of vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma
Author
Hastie, Eric
Date Created
2014
Subjects--Topical
Virology, Biology
Description
Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. Lack of preexisting immunity against VSV, inherent oncotropism, and genetic malleability make VSV a widely used platform for vaccine, oncolytic, and gene ther...