Search results
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Title
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A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
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Author
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Wu, Shuta
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Date Created
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2017
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Subjects--Topical
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Biology, Oncology
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Description
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Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
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Title
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A STRUCTURAL AND FUNCTIONAL ANALYSIS OF NEMATOSTELLA VECTENSIS MAJOR INTRINSIC PROTEINS
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Author
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Taylor, Jonathon
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Date Created
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2020
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Subjects--Topical
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Biology, Cytology, Evolutionary developmental biology
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Description
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There is currently a major gap in understanding the physiological processes of tissue grade animals from early diverging phyla, particularly within the context of the molecular mechanisms in response to osmotic variation. A key protein family esse...
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Title
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ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
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Author
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Farrel, Alvin
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Date Created
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2016
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Subjects--Topical
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Computer science, Biology, Bioinformatics
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Description
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Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...
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Title
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Active Notch signaling is required for arm regeneration in a brittle star
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Author
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Janies, Daniel, Machado, Denis Jacob, Reid, Robert
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Date Created
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2020
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Subjects--Topical
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Genomics, Biology
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Description
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Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including pr...
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Title
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CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
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Author
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Knighton, Laura
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Date Created
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2020
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Subjects--Topical
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Biology, Biochemistry
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Description
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The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
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Title
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COMPARATIVE ANALYSIS OF REPEAT LANDSCAPES IN AVENA (OAT)
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Author
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Burkes, Shelvasha
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Date Created
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2020
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Subjects--Topical
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Biology, Bioinformatics, Botany
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Description
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Avena sativa, or common oat, is a staple crop and member of the Poaceae or Grass family. Following behind wheat, maize and rice, oats account for 10.5 million hectares of the world’s produced crops as of 2017. Phytocompounds such as β-glucan, aven...
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Title
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CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
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Author
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Burcal, Christopher
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Date Created
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2017
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Subjects--Topical
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Biology, Kinesiology, Neurosciences
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Description
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Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...
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Title
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Calculating ensemble averaged descriptions of protein rigidity without sampling
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Author
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Jacobs, Donald J., Gonzalez, Luis C., Wang, Hui, Livesay, Dennis R.
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Date Created
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2012
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Subjects--Topical
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Biology, Proteins
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Description
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Previous works have demonstrated that protein rigidity is related to thermodynamic stability, especially under conditions that favor formation of native structure. Mechanical network rigidity properties of a single conformation are efficiently cal...
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Title
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Characterizing a New Regulator of the ATR Signaling Pathway
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Author
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Biller, Megan
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Date Created
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2022
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Subjects--Topical
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Molecular biology, Biology
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Description
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Cellular responses to DNA damage and replication stress are coordinated by an intricate network of repair pathways known as the DNA damage response (DDR). Central to the DDR is the essential kinase ataxia telangiectasia mutated and Rad3-related (A...