Search results
- Title
- A NOVEL ANTIBODY FOR THE DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA
- Author
- Wu, Shuta
- Date Created
- 2017
- Subjects--Topical
- Biology, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancer with a 5-year survival rate below 10%. Two of the major contributors to this dismal prognosis are late-stage diagnosis and limited treatment options. Common symptoms of PDA ...
- Title
- A subterminal growth zone at arm tip likely underlies life-long indeterminate growth in brittle stars
- Author
- Janies, Daniel, Machado, Denis Jacob, Reid, Robert, Kofsky, Janice
- Date Created
- 2022
- Subjects--Topical
- Genomics, Biology
- Description
- Background Echinoderms are a phylum of marine invertebrates with close phylogenetic relationships to chordates. Many members of the phylum Echinodermata are capable of extensive post-traumatic regeneration and life-long indeterminate growth. Diffe...
- Title
- ALGORITHMS FOR STRUCTURE BASED-PREDICTION OF TRANSCRIPTION FACTOR BINDING SITES
- Author
- Farrel, Alvin
- Date Created
- 2016
- Subjects--Topical
- Computer science, Biology, Bioinformatics
- Description
- Transcription factors (TFs) regulate gene expression through binding to specific target DNA sites. Accurate annotation of transcription factor binding sites (TFBSs) at genome scale represents an essential step toward our understanding of gene regu...
- Title
- APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
- Author
- HOSSAIN, MD AKRAM
- Date Created
- 2021
- Subjects--Topical
- Molecular biology, Biology, Cytology
- Description
- The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...
- Title
- Active Notch signaling is required for arm regeneration in a brittle star
- Author
- Janies, Daniel, Machado, Denis Jacob, Reid, Robert
- Date Created
- 2020
- Subjects--Topical
- Genomics, Biology
- Description
- Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including pr...
- Title
- Apoptotic T-cell derived microparticles containing sonic hedgehog modulate endothelial cell functions in inflammation via rho kinase pathway
- Author
- Attal, Neha
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Impaired vascular regulation as a result of endothelial dysfunction is a major determinant of sepsis-associated liver failure. We have previously shown that inhibition of one signaling molecule rho-kinase (ROCK) predominantly restores endothelial ...
- Title
- BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
- Author
- GHOSH, ANINDITA
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...
- Title
- CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
- Author
- Sharma, Sunita
- Date Created
- 2019
- Subjects--Topical
- Molecular biology, Biology
- Description
- Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...
- Title
- CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
- Author
- Yazdanifar, Mahboubeh
- Date Created
- 2019
- Subjects--Topical
- Biology
- Description
- Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...
- Title
- CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
- Author
- Knighton, Laura
- Date Created
- 2020
- Subjects--Topical
- Biology, Biochemistry
- Description
- The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
- Title
- COMPARATIVE ANALYSIS OF REPEAT LANDSCAPES IN AVENA (OAT)
- Author
- Burkes, Shelvasha
- Date Created
- 2020
- Subjects--Topical
- Biology, Bioinformatics, Botany
- Description
- Avena sativa, or common oat, is a staple crop and member of the Poaceae or Grass family. Following behind wheat, maize and rice, oats account for 10.5 million hectares of the world’s produced crops as of 2017. Phytocompounds such as β-glucan, aven...
- Title
- CORTICAL ACTIVITY OF THE SENSORIMOTOR SYSTEM IN PARTICIPANTS WITH CHRONIC ANKLE INSTABILITY
- Author
- Burcal, Christopher
- Date Created
- 2017
- Subjects--Topical
- Biology, Kinesiology, Neurosciences
- Description
- Patients with chronic ankle instability (CAI) exhibit a wide variety of sensorimotor deficits. These include impairments in feed-forward sensorimotor control (i.e. motor planning) as well as feed-back sensorimotor control, which pertains to refini...
- Title
- Calculating ensemble averaged descriptions of protein rigidity without sampling
- Author
- Jacobs, Donald J., Gonzalez, Luis C., Wang, Hui, Livesay, Dennis R.
- Date Created
- 2012
- Subjects--Topical
- Biology, Proteins
- Description
- Previous works have demonstrated that protein rigidity is related to thermodynamic stability, especially under conditions that favor formation of native structure. Mechanical network rigidity properties of a single conformation are efficiently cal...
- Title
- Characterizing the diversity of heat shock proteins in Nematostella vectensis and Saccharomyces cerevisiae
- Author
- Alexander, William, Reitzel, Adam M., Truman, Andrew
- Date Created
- 2022
- Subjects--Topical
- Heat shock proteins, Biology
- Description
- Heat shock proteins (HSPs) are a highly conserved family of proteins critical to both environmental stress response and cellular function under normal conditions. More specifically HSPs are chaperone proteins that work to refold other misfolded pr...
- Title
- Chemoenzymatic preparation of a Campylobacter jejuni lipid-linked heptasaccharide on an azide-linked polyisoprenoid
- Author
- Reid, Amanda J., Erickson, Katelyn M., Hazel, Joseph M., Troutman, Jerry M.
- Date Created
- 2023
- Subjects--Topical
- Biology, Carbohydrates
- Description
- Complex poly- and oligosaccharides on the surface of bacteria provide a unique fingerprint to different strains of pathogenic and symbiotic microbes that could be exploited for therapeutics or sensors selective for specific glycans. To discover re...
- Title
- Collateral changes in susceptibility of Burkholderia multivorans
- Author
- Flanagan, Jerilyn
- Date Created
- 2019
- Subjects--Topical
- Biology, Microbiology
- Description
- Antibiotic resistant bacteria, particularly in chronic infections, are difficult and costly to treat, so research into detection, identification, and treatment options is critical. Susceptibility measurement must accurately reflect the degree to w...
- Title
- Common Dietary and Environmental Compounds Promote a Leukemic Translocation in Hematopoietic Stem Cells and Differentiated Cells
- Author
- Vestal, Carol
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Maternal exposure to topoisomerase II (topoII) inhibitors that are biochemically similar to the chemotherapeutic drug etoposide may promote infant acute leukemia. Several studies have shown that common dietary bioflavonoids as well as benzene meta...
- Title
- Comparative analysis of Nitrosococcus genomes; isolation, physiological and genomic characterization of the new ammonia-oxidizing species Nitrosococcus wardiae, strain D1FHST; and molecular studies towards a better understanding of ammonia-dependent chemolithotrophy
- Author
- Wang, Lin
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Biology, Genetics
- Description
- Obligate aerobic chemolithoautotrophic ammonia-oxidzing bacteria (AOB) derive energy and reductant needed for growth solely from the oxidation of ammonia to nitrite thereby facilitating the process of nitritation. A strain of an ammonia-oxidizing ...
- Title
- Content and sentiment surveillance (CSI) : A critical component for modeling modern epidemics
- Author
- Janies, Daniel, Chen, Shi, Zhang, Dongsong
- Date Created
- 2023
- Subjects--Topical
- Communicable diseases, Biology
- Description
- Comprehensive surveillance systems are the key to provide accurate data for effective modeling. Traditional symptom-based case surveillance has been joined with recent genomic, serologic, and environment surveillance to provide more integrated dis...
- Title
- Convergent shifts in host-associated microbial communities across environmentally elicited phenotypes
- Author
- Reitzel, Adam M., Carrier, Tyler J.
- Date Created
- 2018
- Subjects--Topical
- Evolution (Biology), Biology
- Description
- Morphological plasticity is a genotype-by-environment interaction that enables organisms to increase fitness across varying environments. Symbioses with diverse microbiota may aid in acclimating to this variation, but whether the associated bacter...