Search results | J. Murrey Atkins Library

Title: Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
Author: Bose, Mukulika
Date Created: 2022
Subjects--Topical: Molecular biology, Biochemistry, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...

Title: Analysis and Development of Targeting Strategies for Bacterial Sugars
Author: Erickson, Katelyn
Date Created: 2018
Subjects--Topical: Chemistry, Biochemistry
Description: Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...

Title: Assessing the Biological Activities of DNA-Templated Silver Nanoclusters and Furthering the Characterization of Nucleic Acid Nanoparticles
Author: Rolband, Lewis
Date Created: 2023
Subjects--Topical: Biochemistry
Description: DNA and RNA are structurally and functionally diverse biopolymers that haveshown promise in recent years as a powerful biomedical tool, in the form of nucleic acid nanotechnologies. The applications of these technologies include biosensing, diagno...

Title: CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Author: Patil, Sushant
Date Created: 2016
Subjects--Topical: Molecular biology, Bioinformatics, Biochemistry
Description: Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...

Title: CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
Author: Knighton, Laura
Date Created: 2020
Subjects--Topical: Biology, Biochemistry
Description: The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...

Title: Characterization of the Colanic Acid Biosynthesis Pathway with a Fluorescent Bactoprenyl Monophosphate Analogue
Author: Scott, Phillip
Date Created: 2015
Subjects--Topical: Biochemistry
Description: When introduced to harsh conditions such as low pH, pathogenic Escherichia coli can secrete colanic acid, an exopolysaccharide that completely engulfs the organism, to establish a protective barrier between the organism and the acidic environment....

Title: ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
Author: Okwei, Elleansar
Date Created: 2016
Subjects--Topical: Chemistry, Biology, Biochemistry
Description: The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...

Title: Exceptional New Reagents for Bioconjugation
Author: Garmon, Corey
Date Created: 2016
Subjects--Topical: Chemistry, Biochemistry
Description: At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...

Title: FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
Author: Ke, Weina
Date Created: 2020
Subjects--Topical: Biochemistry, Cytology
Description: Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...

Title: Folate Receptor-Specific, Redox-Responsive Mesoporous Silica Nanoparticles for the Simultaneous Delivery of Cisplatin and Gemcitabine to Treat Cancer
Author: Fink, Eric
Date Created: 2016
Subjects--Topical: Materials science, Chemistry, Biochemistry
Description: Nanoparticles are an innovative platform for cancer treatment that reduces systemic toxicity and allows for active targeting of tumor sites to enhance the therapeutic efficacy. Mesoporous silica nanoparticles (MSNs) have emerged as an attractive d...

Title: Halogenated Tags for the Investigation of Enzyme Specificity
Author: Houde, Hailey
Date Created: 2023
Subjects--Topical: Biochemistry, Chemistry
Description: The bacterial enzyme undecaprenyl pyrophosphate synthase (UppS) is present in most prokaryotes and is needed for bacterial survival. UppS produces the essential lipid carrier, bactoprenyl monophosphate (BP). BP is critical for the structural integ...

Title: Hybrid solvation models for electrostatic interactions in molecular dynamics simulations of ionic solvent
Author: Xiang, Ming
Date Created: 2012
Subjects--Topical: Mathematics, Biochemistry, Biophysics
Description: In this dissertation, we mainly discuss the image approximation methods to the reaction field and their applications to electrostatic interactions in molecular dynamics simulations. The Poisson-Boltzman (PB) equation, a three-dimensional second or...

Title: INCORPORATION OF FLUORESCENT ANALOGUES IN ISOPRENOID PATHWAYS IN ESCHERICHIA COLI
Author: George, Chelsea
Date Created: 2018
Subjects--Topical: Biochemistry
Description: Bacterial glycans and glycoconjugates have wide diversity compared to their eukaryotic counterparts. While methods have been developed to monitor and track glycans in eukaryotic systems with some success, there are limited methods with which to do...

Title: Investigating the Genetic Basis and Selection of Diverse Plant Specialized Metabolites in Wild Soybean, Glycine soja.
Author: Yasmin, Farida
Date Created: 2023
Subjects--Topical: Botany, Genetics, Biochemistry
Description: Plant-specialized metabolites, such as glyceollins and soyasaponins, play vital roles in adapting to dynamic environments and promoting human health. Glyceollins, induced phytoalexins derived from the isoflavonoid branch of the phenylpropanoid pat...

Title: Mass Spectrometric Protein Footprinting of Conformational Changes Induced by Chromatographic Surfaces
Author: Focke, Kimberly
Date Created: 2022
Subjects--Topical: Analytical chemistry, Biochemistry
Description: Reversed-phase liquid chromatography (RPLC) of intact proteins induces conformational changes due to the denaturing effects of both the hydrophobic stationary phase and the high-organic mobile phase, which can lead to poor recovery and badly disto...

Title: Moisture sorption behavior, stability, and protein formulation characteristics of a trehalose choline chloride eutectic composition
Author: Burgin, Tiffany
Date Created: 2017
Subjects--Topical: Mechanical engineering, Materials science, Biochemistry
Description: Protein based drugs and therapeutics are an important treatment for many life-threatening diseases but they can also be extremely expensive. The unique 3-dimensional structure of a protein is responsible for its function but also contributes to it...

Title: NUCLEIC ACID-DRIVEN QUANTUM DOT-BASED LATTICE FORMATIONS FOR BIOMEDICAL APPLICATIONS
Author: Roark, Brandon
Date Created: 2017
Subjects--Topical: Nanoscience, Nanotechnology, Biochemistry
Description: We present a versatile biosensing strategy that uses nucleic acids programmed to undergo an isothermal toehold mediated strand displacement in the presence of analyte. This rearrangement results in a double biotinylated duplex formation that induc...

Title: ORGANIZATION OF BIOMOLECULES IN A 3-DIMENSIONAL SPACE
Author: Sajja, Sameer
Date Created: 2019
Subjects--Topical: Nanotechnology, Biochemistry
Description: The human body operates using various stimuli-responsive mechanisms, dictating biological activity via reaction to external cues. Hydrogels are networked hydrophilic polymeric materials that offer the potential to recreate aqueous environments wit...

Title: ORGANIZATION OF BIOMOLECULES IN A 3-DIMENSIONAL SPACE
Author: Sajja, Sameer
Date Created: 2019
Subjects--Topical: Biochemistry
Description: The human body operates using various stimuli-responsive mechanisms, dictating biological activity via reaction to external cues. Hydrogels are networked hydrophilic polymeric materials that offer the potential to recreate aqueous environments wit...

Title: RNA Kissing Loop Library to expand RNA Fiber functionality and control cargo load for potential intracellular siRNA delivery.
Author: Shevchenko, Oleg
Date Created: 2020
Subjects--Topical: Nanoscience, Nanotechnology, Biochemistry
Description: A kissing loop (KL) is an RNA motif that among others may have a 180° geometry when derived from a viral genome. The KL interactions of this geometry consist of nine base pairs, six of which are interacting in complementary binding while three are...