- Biochemistry (x)
- Chemistry (x)
- Search results
Search results
- Title
- Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
- Author
- Bose, Mukulika
- Date Created
- 2022
- Subjects--Topical
- Molecular biology, Biochemistry, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...
- Title
- Assessing the Biological Activities of DNA-Templated Silver Nanoclusters and Furthering the Characterization of Nucleic Acid Nanoparticles
- Author
- Rolband, Lewis
- Date Created
- 2023
- Subjects--Topical
- Biochemistry
- Description
- DNA and RNA are structurally and functionally diverse biopolymers that haveshown promise in recent years as a powerful biomedical tool, in the form of nucleic acid nanotechnologies. The applications of these technologies include biosensing, diagno...
- Title
- CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
- Author
- Patil, Sushant
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Bioinformatics, Biochemistry
- Description
- Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...
- Title
- CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
- Author
- Knighton, Laura
- Date Created
- 2020
- Subjects--Topical
- Biology, Biochemistry
- Description
- The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
- Title
- Chemoenzymatic Preparation of Probes for in vitro and Cellular Elucidation of Complex Bacteria Polysaccharides
- Author
- Reid, Amanda
- Date Created
- 2021
- Subjects--Topical
- Microbiology, Biochemistry, Analytical chemistry
- Description
- Bacteria play a major role in our health and wellbeing. The microbe-host interaction is often mediated by sugar polymers at the cell surface. An incredibly diverse amount of glycan variation exists throughout these structures, which makes identifi...
- Title
- Dietary Identity At Salango: Stable Light Isotope Analysis Of Guangala Period Burials (100 BCE – 800 CE)
- Author
- Cobb, Emilie
- Date Created
- 2021
- Subjects--Topical
- Biochemistry, Archaeology
- Description
- Salango is an archaeological site on the coast of Ecuador that has been inhabited for thousands of years by multiple different cultures, including the Guangala (100 BCE- 400 CE). While research about mortuary treatment and socio-cultural character...
- Title
- Exploring the Immune System using Hybrid Cube Nanoparticles
- Author
- McMillan, Jessica
- Date Created
- 2021
- Subjects--Topical
- Biochemistry, Nanotechnology, Biology
- Description
- Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...
- Title
- Hybrid solvation models for electrostatic interactions in molecular dynamics simulations of ionic solvent
- Author
- Xiang, Ming
- Date Created
- 2012
- Subjects--Topical
- Mathematics, Biochemistry, Biophysics
- Description
- In this dissertation, we mainly discuss the image approximation methods to the reaction field and their applications to electrostatic interactions in molecular dynamics simulations. The Poisson-Boltzman (PB) equation, a three-dimensional second or...
- Title
- Investigating the Genetic Basis and Selection of Diverse Plant Specialized Metabolites in Wild Soybean, Glycine soja.
- Author
- Yasmin, Farida
- Date Created
- 2023
- Subjects--Topical
- Botany, Genetics, Biochemistry
- Description
- Plant-specialized metabolites, such as glyceollins and soyasaponins, play vital roles in adapting to dynamic environments and promoting human health. Glyceollins, induced phytoalexins derived from the isoflavonoid branch of the phenylpropanoid pat...
- Title
- Moisture sorption behavior, stability, and protein formulation characteristics of a trehalose choline chloride eutectic composition
- Author
- Burgin, Tiffany
- Date Created
- 2017
- Subjects--Topical
- Mechanical engineering, Materials science, Biochemistry
- Description
- Protein based drugs and therapeutics are an important treatment for many life-threatening diseases but they can also be extremely expensive. The unique 3-dimensional structure of a protein is responsible for its function but also contributes to it...
- Title
- Regulation of Myosin IIIa Motor/Kinase Activity
- Author
- Moore, Judy
- Date Created
- 2009
- Subjects--Topical
- Biochemistry, Neurosciences, Cytology
- Description
- Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...
- Title
- Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
- Author
- Gargey, Akhil
- Date Created
- 2021
- Subjects--Topical
- Molecular biology, Biochemistry, Biophysics
- Description
- Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...
- Title
- Toward understanding protein-DNA interactions
- Author
- Lin, Maoxuan
- Date Created
- 2020
- Subjects--Topical
- Biology, Bioinformatics, Biochemistry
- Description
- Knowledge of protein-DNA interactions has important implications in understandingbiological activities and developing therapeutic drugs. Two types of protein-DNAinteractions exist: (1) interactions between double-stranded DNA-binding proteins(DSBs...
- Title
- Understanding Chaperone interactions in disease
- Author
- Nitika
- Date Created
- 2021
- Subjects--Topical
- Molecular biology, Biochemistry, Cytology
- Description
- The correct folding of proteins after synthesis and stress-promoted denaturation is critical for cell viability in all organisms. The Hsp70 molecular chaperone is a key player in proteostasis, deciding which proteins are foldable and which are too...
- Title
- VPS501, A NOVEL SNX-BAR PROTEIN INVOLVED IN AUTOPHAGY
- Author
- goyal, Shreya
- Date Created
- 2021
- Subjects--Topical
- Biochemistry, Cytology, Molecular biology
- Description
- ABSTRACTCareful control of intracellular signaling pathways plays an important role in a cell’s ability to maintain stable internal conditions in the face of an ever-changing extracellular environment. This is particularly true as it relates to th...