- Biochemistry (x)
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- Title
- Abrogating the oncogenic signaling associated with tumor MUC1 in Pancreatic Ductal Adenocarcinoma
- Author
- Bose, Mukulika
- Date Created
- 2022
- Subjects--Topical
- Molecular biology, Biochemistry, Oncology
- Description
- Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25\% are eligible. Tumor recurrence a...
- Title
- Analysis and Development of Targeting Strategies for Bacterial Sugars
- Author
- Erickson, Katelyn
- Date Created
- 2018
- Subjects--Topical
- Chemistry, Biochemistry
- Description
- Bacterial cell surface exopolysaccharides aid in protecting microbes from the defense mechanisms of the host, and differ substantially in structure between species. Exploiting these structural differences would be advantageous to target certain ty...
- Title
- Assessing the Biological Activities of DNA-Templated Silver Nanoclusters and Furthering the Characterization of Nucleic Acid Nanoparticles
- Author
- Rolband, Lewis
- Date Created
- 2023
- Subjects--Topical
- Biochemistry
- Description
- DNA and RNA are structurally and functionally diverse biopolymers that haveshown promise in recent years as a powerful biomedical tool, in the form of nucleic acid nanotechnologies. The applications of these technologies include biosensing, diagno...
- Title
- CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
- Author
- Patil, Sushant
- Date Created
- 2016
- Subjects--Topical
- Molecular biology, Bioinformatics, Biochemistry
- Description
- Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...
- Title
- CO-CHAPERONE REGULATION OF THE RIBONUCLOETIDE REDUCTASE COMPLEX
- Author
- Knighton, Laura
- Date Created
- 2020
- Subjects--Topical
- Biology, Biochemistry
- Description
- The molecular chaperone Hsp70 folds a significant proportion of the proteome and is responsible for the activity and stability of many disease-related proteins, including those in cancer. Substantial effort has been devoted to developing a range o...
- Title
- Characterization of the Colanic Acid Biosynthesis Pathway with a Fluorescent Bactoprenyl Monophosphate Analogue
- Author
- Scott, Phillip
- Date Created
- 2015
- Subjects--Topical
- Biochemistry
- Description
- When introduced to harsh conditions such as low pH, pathogenic Escherichia coli can secrete colanic acid, an exopolysaccharide that completely engulfs the organism, to establish a protective barrier between the organism and the acidic environment....
- Title
- Chemoenzymatic Preparation of Probes for in vitro and Cellular Elucidation of Complex Bacteria Polysaccharides
- Author
- Reid, Amanda
- Date Created
- 2021
- Subjects--Topical
- Microbiology, Biochemistry, Analytical chemistry
- Description
- Bacteria play a major role in our health and wellbeing. The microbe-host interaction is often mediated by sugar polymers at the cell surface. An incredibly diverse amount of glycan variation exists throughout these structures, which makes identifi...
- Title
- Dietary Identity At Salango: Stable Light Isotope Analysis Of Guangala Period Burials (100 BCE – 800 CE)
- Author
- Cobb, Emilie
- Date Created
- 2021
- Subjects--Topical
- Biochemistry, Archaeology
- Description
- Salango is an archaeological site on the coast of Ecuador that has been inhabited for thousands of years by multiple different cultures, including the Guangala (100 BCE- 400 CE). While research about mortuary treatment and socio-cultural character...
- Title
- ELUCIDATING THE MOLECULAR BASIS OF INHIBITION OF ENZYMES ESSENTIAL FOR BATERIALVIRULENCE: THE ACTIVITY OF THREE GLYCOSYLTRANSFERASES AND A POTENTIAL DRUG TARGET, UNDECAPRENYL PYROPHOSPHATE SYNTHASE
- Author
- Okwei, Elleansar
- Date Created
- 2016
- Subjects--Topical
- Chemistry, Biology, Biochemistry
- Description
- The fight against bacterial infection is one of the most important branches of modern medicine. Due to the emergence of strains of antibiotic-resistant bacteria, researchers have been presented with complex challenges in an effort to combat these ...
- Title
- Exceptional New Reagents for Bioconjugation
- Author
- Garmon, Corey
- Date Created
- 2016
- Subjects--Topical
- Chemistry, Biochemistry
- Description
- At about the turn of this century the term "click" chemistry came into the common vernacular amongst chemists. "Click" is used to describe reactions that are "spring-loaded" and proceed well in a predictable manner, with no offensive byproduct and...
- Title
- Exploring the Immune System using Hybrid Cube Nanoparticles
- Author
- McMillan, Jessica
- Date Created
- 2021
- Subjects--Topical
- Biochemistry, Nanotechnology, Biology
- Description
- Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...
- Title
- FUNCTIONAL NUCLEIC ACID NANOPARTICLES AND THEIR DELIVERY
- Author
- Ke, Weina
- Date Created
- 2020
- Subjects--Topical
- Biochemistry, Cytology
- Description
- Nucleic acid biopolymers are essential to all living organisms. The chemical makeup of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of sequences of only four monomers. However, they transmit and express genetic information for va...
- Title
- Folate Receptor-Specific, Redox-Responsive Mesoporous Silica Nanoparticles for the Simultaneous Delivery of Cisplatin and Gemcitabine to Treat Cancer
- Author
- Fink, Eric
- Date Created
- 2016
- Subjects--Topical
- Materials science, Chemistry, Biochemistry
- Description
- Nanoparticles are an innovative platform for cancer treatment that reduces systemic toxicity and allows for active targeting of tumor sites to enhance the therapeutic efficacy. Mesoporous silica nanoparticles (MSNs) have emerged as an attractive d...
- Title
- Halogenated Tags for the Investigation of Enzyme Specificity
- Author
- Houde, Hailey
- Date Created
- 2023
- Subjects--Topical
- Biochemistry, Chemistry
- Description
- The bacterial enzyme undecaprenyl pyrophosphate synthase (UppS) is present in most prokaryotes and is needed for bacterial survival. UppS produces the essential lipid carrier, bactoprenyl monophosphate (BP). BP is critical for the structural integ...
- Title
- Hybrid solvation models for electrostatic interactions in molecular dynamics simulations of ionic solvent
- Author
- Xiang, Ming
- Date Created
- 2012
- Subjects--Topical
- Mathematics, Biochemistry, Biophysics
- Description
- In this dissertation, we mainly discuss the image approximation methods to the reaction field and their applications to electrostatic interactions in molecular dynamics simulations. The Poisson-Boltzman (PB) equation, a three-dimensional second or...
- Title
- INCORPORATION OF FLUORESCENT ANALOGUES IN ISOPRENOID PATHWAYS IN ESCHERICHIA COLI
- Author
- George, Chelsea
- Date Created
- 2018
- Subjects--Topical
- Biochemistry
- Description
- Bacterial glycans and glycoconjugates have wide diversity compared to their eukaryotic counterparts. While methods have been developed to monitor and track glycans in eukaryotic systems with some success, there are limited methods with which to do...
- Title
- Mass Spectrometric Protein Footprinting of Conformational Changes Induced by Chromatographic Surfaces
- Author
- Focke, Kimberly
- Date Created
- 2022
- Subjects--Topical
- Analytical chemistry, Biochemistry
- Description
- Reversed-phase liquid chromatography (RPLC) of intact proteins induces conformational changes due to the denaturing effects of both the hydrophobic stationary phase and the high-organic mobile phase, which can lead to poor recovery and badly disto...
- Title
- Moisture sorption behavior, stability, and protein formulation characteristics of a trehalose choline chloride eutectic composition
- Author
- Burgin, Tiffany
- Date Created
- 2017
- Subjects--Topical
- Mechanical engineering, Materials science, Biochemistry
- Description
- Protein based drugs and therapeutics are an important treatment for many life-threatening diseases but they can also be extremely expensive. The unique 3-dimensional structure of a protein is responsible for its function but also contributes to it...
- Title
- NUCLEIC ACID-DRIVEN QUANTUM DOT-BASED LATTICE FORMATIONS FOR BIOMEDICAL APPLICATIONS
- Author
- Roark, Brandon
- Date Created
- 2017
- Subjects--Topical
- Nanoscience, Nanotechnology, Biochemistry
- Description
- We present a versatile biosensing strategy that uses nucleic acids programmed to undergo an isothermal toehold mediated strand displacement in the presence of analyte. This rearrangement results in a double biotinylated duplex formation that induc...
- Title
- ORGANIZATION OF BIOMOLECULES IN A 3-DIMENSIONAL SPACE
- Author
- Sajja, Sameer
- Date Created
- 2019
- Subjects--Topical
- Nanotechnology, Biochemistry
- Description
- The human body operates using various stimuli-responsive mechanisms, dictating biological activity via reaction to external cues. Hydrogels are networked hydrophilic polymeric materials that offer the potential to recreate aqueous environments wit...