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APE2 promotes DNA damage response pathway from a single-strand break
Title
APE2 promotes DNA damage response pathway from a single-strand break
Author
Yan, Shan, Lin, Yunfeng, Bai, Liping, Cupello, Steven
Date Created
2018
Subjects--Topical
Cancer--Research, DNA
Description
As the most common type of DNA damage, DNA single-strand breaks (SSBs) are primarily repaired by the SSB repair mechanism. If not repaired properly or promptly, unrepaired SSBs lead to genome stability and have been implicated in cancer and neurod...
Commonality of functional annotation : a method for prioritization of candidate genes from genome-wide linkage studies
Title
Commonality of functional annotation : a method for prioritization of candidate genes from genome-wide linkage studies
Author
Loraine, Ann, Shriner, Daniel, Baye, Tesfaye M., Padilla, Miguel A.
Date Created
2008
Subjects--Topical
Gene expression, Alzheimer's disease
Description
Linkage studies of complex traits frequently yield multiple linkage regions covering hundreds of genes. Testing each candidate gene from every region is prohibitively expensive and computational methods that simplify this process would benefit gen...
In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei
Title
In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei
Author
Chakrabarti, Kausik, Dey, Abishek, Klotz, Kaitlin, Davis, Justin, Monroy-Eklund, Anais, Saha, Arpita, Li, Bibo, Laederach, Alain
Subjects--Topical
RNA, Nucleoproteins
Description
Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, TR, as i...