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Hydrogen bond energy-based comparative analysis of protein-ligand interactions and similarity assessment of protein-DNA complex models
Title
Hydrogen bond energy-based comparative analysis of protein-ligand interactions and similarity assessment of protein-DNA complex models
Author
Malik, Fareeha
Date Created
2022
Subjects--Topical
Bioinformatics, Computer science
Description
Hydrogen bonds play a vital role in protein-DNA interactions. In particular, side chain-base hydrogen bonds are crucial to the binding specificity between protein and DNA. Mutations effecting interface hydrogen bonds in protein-DNA complexes have ...
Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Title
Investigation and Analysis of Context Dependent Mutation Rates Contribution to Synonymous Mutation Codon Usage via Development of CDMAP.
Author
Patton, David
Date Created
2022
Subjects--Topical
Bioinformatics, Molecular biology, Biometry
Description
Mutations play a pivotal role as a driver of genome evolution in organisms across the tree of life. However, site-specific mutation rates appear to have a non-uniform mutation rate and vary across the genome. Currently, site-specific variation has...
Nutritive Knowledge Based Discovery: Enhancing Precision Nutrition Hypothesis Generation
Title
Nutritive Knowledge Based Discovery: Enhancing Precision Nutrition Hypothesis Generation
Author
Trautman, Aaron
Date Created
2022
Subjects--Topical
Bioinformatics, Nutrition, Information science
Description
Diet-related diseases like obesity and type-2 diabetes are on the rise. Precision nutrition, a way to tailor dietary requirements for each individual, is heralded as a solution to these problems. However, nutritional research is held within sparse...
On Compositionally Aware and Naïve Approaches to Normalization of 16S Microbiome Data
Title
On Compositionally Aware and Naïve Approaches to Normalization of 16S Microbiome Data
Author
Yerke, Aaron
Date Created
2022
Subjects--Topical
Bioinformatics
Description
Compositional data refers to any data that represents parts of a whole, and DNA sequencing data is compositional in nature. This is due to the constraint on our current sequencing technologies that allow us to record a sample of the sequences rath...
On Whole Genome Classifier Perforamnce in Relation to 16S Classifiers
Title
On Whole Genome Classifier Perforamnce in Relation to 16S Classifiers
Author
Johnson, James
Date Created
2022
Subjects--Topical
Bioinformatics
Description
There is little consensus in the literature as to which approach for classification of Whole Genome Shotgun (WGS) sequences is most accurate unlike 16S classifiers that have had more time to mature. In this dissertation, two of the most popular cl...