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APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Title
APE2 is a Critical Regulator of the DNA Damage Response to Maintain Genome Integrity in Mammalian Cells
Author
HOSSAIN, MD AKRAM
Date Created
2021
Subjects--Topical
Molecular biology, Biology, Cytology
Description
The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required for the activation of an ATR-Chk1 DNA damage response (DDR) pathway in response...
Cranial Capacity Variation of Pleistocene Homo and Possible Speciation Events
Title
Cranial Capacity Variation of Pleistocene Homo and Possible Speciation Events
Author
Hudock, Autumn
Date Created
2021
Subjects--Topical
Biology, Paleontology, Evolutionary developmental biology
Description
The field of paleoanthropology is tasked with studying the morphology of extinct hominins using fossilized remains. To study the evolution of the human brain, researchers use endocast data derived from fossil skulls, in order to assess when and ho...
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Title
Design and Modulation of Novel Chemical Probes for RNA SHAPE Analysis: Water Soluble Isatoic Anhydrides and Nicotinic Acid Imidazolides
Author
Fessler, Adam
Date Created
2021
Subjects--Topical
Chemistry, Biology
Description
The growing interest in RNA biology, along with an expansion in computational capabilities, throughput, and sensitivity has provided researchers new tools to probe RNA. RNA selective 2′-hydroxy acylation analyzed by primer extension (SHAPE) utiliz...
Disulfide-trapped CXCL12-CXCL4 Chemokine Heterodimers Prevent Breast Cancer Progression
Title
Disulfide-trapped CXCL12-CXCL4 Chemokine Heterodimers Prevent Breast Cancer Progression
Author
Nguyen, Khanh
Date Created
2021
Subjects--Topical
Biology
Description
Triple negative breast cancers (TNBCs), i.e., 10-15% of diagnosed breast cancers, have a triple negative (Her/2-, ER- and PR-) phenotype and are the most aggressive subtype of breast cancer. TNBCs have a worst prognosis because of the high probabi...
Exploring the Immune System using Hybrid Cube Nanoparticles
Title
Exploring the Immune System using Hybrid Cube Nanoparticles
Author
McMillan, Jessica
Date Created
2021
Subjects--Topical
Biochemistry, Nanotechnology, Biology
Description
Nano-sized cubes made from nucleic acid material (NANPs) are ideal scaffolds for therapeutic nucleic acids (TNAs). Both utilize sequence specificity through base-pairing, providing controlled strand interaction, stability, and targeted targeting d...
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Title
Inflammation, NLRP3 Inflammasomes, Macrophages and Breast Cancer Progression
Author
Holtzman , Katherine
Date Created
2021
Subjects--Topical
Biology, Immunology, Oncology
Description
One in 8 women will be diagnosed with breast cancer in their lifetime and while breast cancer mortality has declined since the 1980s, it remains the 2nd leading cause of cancer-related deaths among women. Standard of care is determined by anatomic...
Screening of FDA-Approved Drug Library for Combinatorial Treatment of Pancreatic Ductal Adenocarcinoma Cells with Oncolytic Vesicular Stomatitis Virus
Title
Screening of FDA-Approved Drug Library for Combinatorial Treatment of Pancreatic Ductal Adenocarcinoma Cells with Oncolytic Vesicular Stomatitis Virus
Author
Holbrook, Molly
Date Created
2021
Subjects--Topical
Biology
Description
Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with poor prognosis and a dismal survival rate, expected to become the second leading cause of cancer-related deaths in the United States. Oncolytic virus (OV) is an anticancer ap...
Study of Enzymes Required for the Synthesis of the Enterobacterial Common Antigen in Vitro
Title
Study of Enzymes Required for the Synthesis of the Enterobacterial Common Antigen in Vitro
Author
Oliverio, Cassidy
Date Created
2021
Subjects--Topical
Biology
Description
In recent years, the Center for Disease Control (CDC) has highlighted many bacteria as being either serious or urgent threats in terms of antibiotic resistance such as Salmonella enterica, Klebsiella, and Shigella. These bacteria are all members o...
The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Title
The in-vivo Evolution of Burkholderia multivorans in a Cystic Fibrosis patient
Author
Harrison, Sarah
Date Created
2021
Subjects--Topical
Biology, Microbiology, Bioinformatics
Description
ABSTRACT Burkholderia multivorans is an opportunistic pathogen that poses a health risk to patients with cystic fibrosis (CF). The use of broad-range antibiotics to combat chronic bacterial lung infections has led to the evolution of antibiotic-re...