Search results | J. Murrey Atkins Library

Title: EXPERIMENTAL EVOLUTION OF ONCOLYTIC VESICULAR STOMATITIS VIRUSES IN CANCER CELLS
Author: Seegers, Sara
Date Created: 2019
Subjects--Topical: Molecular biology, Virology, Biology
Description: Vesicular stomatitis virus (VSV) based oncolytic viruses are promising agents against various cancers. We have shown that pancreatic ductal adenocarcinoma (PDAC) cell lines exhibit great diversity in susceptibility and permissibility to VSV. Here,...

Title: BIOFLAVONOIDS GENISTEIN AND QUERCETIN TRIGGER ALTERNATIVE END JOINING PATHWAY OF DNA REPAIR
Author: GHOSH, ANINDITA
Date Created: 2019
Subjects--Topical: Biology
Description: Faithful repair of chromosomal double-strand breaks (DSBs) is crucial to genome stability and normal cell survival and proliferation. During normal metabolic processes and especially following exposure to DNA damaging agents including irradiation,...

Title: Apoptotic T-cell derived microparticles containing sonic hedgehog modulate endothelial cell functions in inflammation via rho kinase pathway
Author: Attal, Neha
Date Created: 2019
Subjects--Topical: Biology
Description: Impaired vascular regulation as a result of endothelial dysfunction is a major determinant of sepsis-associated liver failure. We have previously shown that inhibition of one signaling molecule rho-kinase (ROCK) predominantly restores endothelial ...

Title: Genomic Dissection of Complex Trait Variation in Wild Soybean, Glycine soja
Author: Kofsky, Janice
Date Created: 2019
Subjects--Topical: Biology, Bioinformatics, Plant diseases
Description: There is a considerable demand for crop improvement, especially considering the growing population, continuing climatic fluctuations, and rapidly evolving plant pests and pathogens. Crop wild relatives hold great potential in providing beneficial ...

Title: MUC1 MEDIATED SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA
Author: Grover, Priyanka
Date Created: 2019
Subjects--Topical: Biology
Description: In 2019, Pancreatic Cancer (PC) is the 3rd leading cause of cancer-related deaths in the USA with 94% dying within 5 years of diagnosis. 90% of PC is Pancreatic Ductal Adenocarcinoma (PDA), of which >80% overexpress a hypo-glycosylated form the me...

Title: Detrimental brain inflammation and the role of the interleukin 10 family members
Author: Burmeister, Amanda
Date Created: 2019
Subjects--Topical: Biology
Description: Resident brain cells recognize pathogens and can initiate and/or regulate inflammation. Indeed, we have shown that stimulated glial cells rapidly produce inflammatory mediators, followed by the late production of anti-inflammatory cytokines such a...

Title: CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL IMMUNOTHERAPY FOR MUCIN 1 (MUC1)-POSITIVE PANCREATIC DUCTAL ADENOCARCINOMA
Author: Yazdanifar, Mahboubeh
Date Created: 2019
Subjects--Topical: Biology
Description: Chimeric antigen receptor engineered (CAR) T cells have shown remarkable success in the treatment of hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors. Pancreatic ductal adenocarcinoma (PDA) is a fatal m...

Title: CHARACTERIZATION OF THE BIOSYNTHETIC PATHWAY OF CAPSULAR POLYSACCHARIDE A IN BACTEROIDES FRAGILIS
Author: Sharma, Sunita
Date Created: 2019
Subjects--Topical: Molecular biology, Biology
Description: Capsular Polysaccharide A (CPSA) is a polymer of a tetrasaccharide unit found on the surface of the symbiotic gut bacteria Bacteroides fragilis. It has been suggested that CPSA is vital for maintaining a normal balance between the levels of Th1 an...

Title: Collateral changes in susceptibility of Burkholderia multivorans
Author: Flanagan, Jerilyn
Date Created: 2019
Subjects--Topical: Biology, Microbiology
Description: Antibiotic resistant bacteria, particularly in chronic infections, are difficult and costly to treat, so research into detection, identification, and treatment options is critical. Susceptibility measurement must accurately reflect the degree to w...

Title: THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
Author: Cupello, Steven
Date Created: 2019
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...

Title: Diel patterning in the bacterial community associated with the sea anemone Nematostella vectensis
Author: Reitzel, Adam M., Leach, Whitney B., Carrier, Tyler J.
Date Created: 2019
Subjects--Topical: Gene expression, Biology
Description: Microbes can play an important role in the physiology of animals by providing essential nutrients, inducing immune pathways, and influencing the specific species that compose the microbiome through competitive or facilitatory interactions. The com...

Title: Linear mitochondrial genome in Anthozoa (Cnidaria) : a case study in Ceriantharia
Author: Reitzel, Adam M., Stampar, Sergio N., Macrander, Jason
Date Created: 2019
Subjects--Topical: Gene expression, Biology
Description: Sequences and structural attributes of mitochondrial genomes have played a critical role in the clarification of relationships among Cnidaria, a key phylum of early-diverging animals. Among the major lineages of Cnidaria, Ceriantharia (tube anemon...

Title: Updated phylogeny of chikungunya virus suggests lineage-specific RNA architecture
Author: Janies, Daniel
Date Created: 2019
Subjects--Topical: Communicable diseases, Biology
Description: Chikungunya virus (CHIKV), a mosquito-borne alphavirus of the family Togaviridae, has recently emerged in the Americas from lineages from two continents: Asia and Africa. Historically, CHIKV circulated as at least four lineages worldwide with both...