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Bioinformatics and biomolecular tools for biomarker discovery in peripheral blood lymphocytes from patients with Sporadic Amyotrophic Lateral Sclerosis
Title
Bioinformatics and biomolecular tools for biomarker discovery in peripheral blood lymphocytes from patients with Sporadic Amyotrophic Lateral Sclerosis
Author
Baciu, Cristina
Date Created
2012
Subjects--Topical
Bioinformatics
Description
Sporadic Amyotrophic lateral sclerosis (sALS) is a complex, invariably fatal, disease with a poorly understood cause, despite many studies. Diagnostic biomarkers that precede active symptoms would be an immense help to clinicians, for patient mana...
CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Title
CHARACTERIZING NEXT-GENERATION SEQUENCING (NGS) PLATFORMS FOR MULTIPLEXED BIOSENSING AND APTAMER DISCOVERY: G-QUADRUPLEX APTAMERS AS A CASE STUDY
Author
Patil, Sushant
Date Created
2016
Subjects--Topical
Molecular biology, Bioinformatics, Biochemistry
Description
Aptamers are single-stranded DNA or RNA molecules forming unique three dimensional structures that can bind to their targets (generally proteins or metabolites or other nucleic acids) with high specificity and affinity. Screening for aptamers requ...
Microarray tools and analysis methods to better characterize biological networks
Title
Microarray tools and analysis methods to better characterize biological networks
Author
Overall, Christopher
Date Created
2012
Subjects--Topical
Bioinformatics
Description
To accurately model a biological system (e.g. cell), we first need to characterize each of its distinct networks. While omics data has given us unprecedented insight into the structure and dynamics of these networks, the associated analysis routin...
The effect of structure in short regions of DNA on measurements on short-oligonucleotide microarray and Ion Torrent PGM sequencing platforms
Title
The effect of structure in short regions of DNA on measurements on short-oligonucleotide microarray and Ion Torrent PGM sequencing platforms
Author
Khoshnevis, Saeed
Date Created
2013
Subjects--Topical
Bioinformatics
Description
Single-stranded DNA in solution has been studied by biophysicists for many years, as complex structures, both stable and dynamic, form under normal experimental conditions. Stable intra-strand formations affect enzymatic technical processes such a...