Search results | J. Murrey Atkins Library

Title: Cholera Toxin Subunit B-Mediated Intracellular Trafficking of Mesoporous Silica Nanoparticles Toward the Endoplasmic Reticulum
Author: Walker, William
Date Created: 2015
Subjects--Topical: Materials science, Nanoscience, Biomedical engineering
Description: In recent decades, pharmaceutical research has led to the development of numerous treatments for human disease. Nanoscale delivery systems have the potential to maximize therapeutic outcomes by enabling target specific delivery of these therapeuti...

Title: DESIGN, SYNTHESIS AND CHARACTERIZATION OF MULTIFUNCTIONAL REDOX-RESPONSIVE PORPHYRIN-BASED POLYSILSESQUIOXANE NANOMATERIALS FOR PHOTODYNAMIC THERAPY
Author: Vega, Daniel
Date Created: 2015
Subjects--Topical: Materials science, Chemistry, Nanotechnology
Description: Photodynamic Therapy (PDT) is a minimally invasive clinically approved cancertreatment that was first applied in the early 20th century. PDT is an attractive alternative when compared to chemotherapy and radiation therapy due to the lack of harmfu...

Title: Design, Synthesis, Characterization and Simulation of Polyhedral Oligomeric Silsesquioxane Porphyrin Molecules to Fabricate Self-Assembled Nanoparticles and Their Use for Photodynamic Therapy
Author: Loman-Cortes, Paula
Date Created: 2021
Subjects--Topical: Nanoscience
Description: PAULA LOMAN-CORTES. Design, Synthesis, Characterization and Simulation of Polyhedral Oligomeric Silsesquioxane Porphyrin Molecules to Fabricate Self-Assembled Nanoparticles and Their Use for Photodynamic Therapy. (Under the direction of DR JUAN L ...

Title: Development of Silica Based Nanoparticles for Multimodal Therapeutic Delivery
Author: Vadarevu, Hemapriyadarshini
Date Created: 2022
Subjects--Topical: Nanoscience
Description: Chronic diseases like cancer are characterized by complex interactions between multiple pathways leading to treatment resistance and invasiveness. Repeated cycles of cytotoxic monotherapies are susceptible to drug resistance induced by the upregul...

Title: Development of nanoparticle-based approaches for the treatment and imaging of pancreatic cancer
Author: Tarannum, Mubin
Date Created: 2020
Subjects--Topical: Nanoscience, Chemistry
Description: Pancreatic ductal adenocarcinoma (PDAC) is a type of exocrine pancreatic cancer which accounts for over 90% of cases. PDAC is the fourth-leading cause of cancer-related mortality in the United States with a 5-year survival rate of 9% with little t...

Title: Folate Receptor-Specific, Redox-Responsive Mesoporous Silica Nanoparticles for the Simultaneous Delivery of Cisplatin and Gemcitabine to Treat Cancer
Author: Fink, Eric
Date Created: 2016
Subjects--Topical: Materials science, Chemistry, Biochemistry
Description: Nanoparticles are an innovative platform for cancer treatment that reduces systemic toxicity and allows for active targeting of tumor sites to enhance the therapeutic efficacy. Mesoporous silica nanoparticles (MSNs) have emerged as an attractive d...

Title: Influence of Functional Groups on the Photodynamic Therapy and Internalization of Porphyrin Modified Polyhedral Oligomeric Silsesquioxane (POSS) Molecules in Mammalian Cells
Author: Johnston, Alexis
Date Created: 2020
Subjects--Topical: Chemistry, Chemistry, Inorganic, Chemistry, Organic
Description: Polyhedral Oligomeric Silsesquioxane (POSS) molecules are highly ordered organic- inorganic hybrid materials with a cage like core of alternating silicon and oxygen atoms surrounded by eight pedant organic residues. These compounds are well-define...

Title: SYNTHESIS OF PORPHYRIN-BASED POLYHEDRAL OLIGOMERIC SILSESQUIOXANE MOLECULES FOR IMPROVED PHOTODYNAMIC THERAPY OF CANCER CELLS
Author: Siano, Paolo
Date Created: 2020
Subjects--Topical: Chemistry
Description: Polyhedral Oligomeric Silsesquioxane (POSS) materials are a class of nanostructured compounds based on Si-O linkages forming a cage with a silicon atom at each vertex, where substituents are bound tetrahedrally determining the physical and chemica...

Title: SYNTHESIS, CHARACTERIZATION, AND APPLICATION OF SILICA-BASED NANOPARTICULATE PLATFORMS FOR THE DELIVERY OF PHOTOSENSITIZERS IN THE USE OF PHOTODYNAMIC THERAPY FOR CANCER TREATMENT
Author: Lyles, Zachary
Date Created: 2018
Subjects--Topical: Nanoscience
Description: Triple negative breast cancer (TNBC) is a subtype of breast cancer which lacks expressions of hormonal receptors (ER/PR/HER2) and other meaningful targets. TNBC is characterized by intra-tumoral heterogeneities, high proliferative activity, poor p...

Title: THE SYNTHESIS OF PHOTOSENSITIZERS FOR THE PHOTODYNAMIC INACTIVATION OF ESCHERICHIA COLI
Author: Hurst, Alexandra
Date Created: 2017
Subjects--Topical: Chemistry
Description: The development of antibiotic resistance is a natural phenomenon that occurs when bacteria cells exchange resistant traits amongst each other or when mutations occur during replication. This causes bacteria to be able to withstand attack by antibi...